TY  - JOUR
PY  - 2023//
TI  - Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits
JO  - Psychological medicine
A1  - Otsuka, Ikuo
A1  - Galfalvy, Hanga
A1  - Guo, Jia
A1  - Akiyama, Masato
A1  - Rujescu, Dan
A1  - Turecki, Gustavo
A1  - Hishimoto, Akitoyo
A1  - Mann, J. John
SP  - 2689
EP  - 2697
VL  - 53
IS  - 6
N2  - BACKGROUND: Suicidal behavior is moderately heritable and a consequence of a combination of the diathesis traits for suicidal behavior and suicide-related major psychiatric disorders. Here, we sought to examine shared polygenic effects between various psychiatric disorders/traits and suicidal behavior and to compare the shared polygenic effects of various psychiatric disorders/traits on non-fatal suicide attempt and suicide death. <br><br>METHODS: We used our genotyped European ancestry sample of 260 non-fatal suicide attempters, 317 suicide decedents and 874 non-psychiatric controls to test whether polygenic risk scores (PRSs) obtained from large GWASs for 22 suicide-related psychiatric disorders/traits were associated with suicidal behavior. <br><br>RESULTS were compared between non-fatal suicide attempt and suicide death in a sensitivity analysis. <br><br>RESULTS: PRSs for major depressive disorder, bipolar disorder, schizophrenia, ADHD, alcohol dependence, sensitivity to environmental stress and adversity, educational attainment, cognitive performance, and IQ were associated with suicidal behavior (Bonferroni-corrected p < 2.5 × 10(-4)). The polygenic effects of all 22 psychiatric disorders/traits had the same direction (p for binomial tests = 4.8 × 10(-7)) and were correlated (Spearman's ρ = 0.85) between non-fatal suicide attempters and suicide decedents. <br><br>CONCLUSIONS: We found that polygenic effects for major psychiatric disorders and diathesis-related traits including stress responsiveness and intellect/cognitive function contributed to suicidal behavior. While we found comparable polygenic architecture between non-fatal suicide attempters and suicide decedents based on correlations with PRSs of suicide-related psychiatric disorders/traits, our analyses are limited by small sample size resulting in low statistical power to detect difference between non-fatal suicide attempt and suicide death.<p />  <p>Language: en</p>
LA  - en
SN  - 0033-2917
UR  - http://dx.doi.org/10.1017/S0033291721004700
ID  - ref1
ER  -