TY  - JOUR
PY  - 2023//
TI  - Body mass index and clinical outcomes in individuals with major depressive disorder: findings from the GSRD European Multicenter Database
JO  - Journal of affective disorders
A1  - Kraus, Christoph
A1  - Kautzky, Alexander
A1  - Watzal, Victoria
A1  - Gramser, Anna
A1  - Kadriu, Bashkim
A1  - Deng, Zhi-De
A1  - Bartova, Lucie
A1  - Zarate, Carlos A. Jr
A1  - Lanzenberger, Rupert
A1  - Souery, Daniel
A1  - Montgomery, Stuart
A1  - Mendlewicz, Julien
A1  - Zohar, Joseph
A1  - Fanelli, Giuseppe
A1  - Serretti, Alessandro
A1  - Kasper, Siegfried
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Individuals with major depressive disorder (MDD) are at higher risk for obesity. In turn, weight gain is a predisposing factor for depression. Although clinical data are sparse, suicide risk also appears to be elevated in obese patients. This study used data from the European Group for the Study of Resistant Depression (GSRD) to investigate clinical outcomes associated with body mass index (BMI) in MDD. <br><br>METHODS: Data were drawn from 892 participants with MDD over the age of 18 years (580 female, 50.5 ± 13.6 years). Response and resistance to antidepressant medication, depression rating scale scores, and further clinical and sociodemographic variables were compared using multiple logistic and linear regressions controlled for age, sex, and risk of weight gain due to psychopharmacotherapy. <br><br>RESULTS: Of the 892 participants, 323 were categorized as treatment-responsive and 569 as treatment-resistant. Within this cohort, 278 (31.1 %) were overweight (BMI = 25-29.9 kg/m(2)) and 151 (16.9 %) were obese (BMI > 30 kg/m(2)). Elevated BMI was significantly associated with higher suicidality, longer duration of psychiatric hospitalizations over their lifetimes, earlier age of onset of MDD, and comorbidities. There was a trend-wise association of BMI with treatment resistance. LIMITATIONS: Data were analyzed in a retrospective, cross-sectional design. BMI was used as an exclusive measure of overweight and obesity. <br><br>CONCLUSIONS: Participants with comorbid MDD and overweight/obesity were at risk for worse clinical outcomes, suggesting that weight gain should be closely monitored in individuals with MDD in daily clinical practice. Further studies are needed to explore the neurobiological mechanisms linking elevated BMI to impaired brain health.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2023.05.042
ID  - ref1
ER  -