TY  - JOUR
PY  - 2023//
TI  - Suicidal ideation and non-suicidal self-injury following early childhood psychotic experiences in preadolescent children at familial high risk of schizophrenia or bipolar disorder-the Danish High Risk and Resilience Study, VIA 11
JO  - Schizophrenia bulletin
A1  - Gregersen, Maja
A1  - Jepsen, Jens Richardt Møllegaard
A1  - Brandt, Julie Marie
A1  - Søndergaard, Anne
A1  - Rohd, Sinnika Birkehøj
A1  - Veddum, Lotte
A1  - Knudsen, Christina Bruun
A1  - Andreassen, Anna Krogh
A1  - Burton, Birgitte Klee
A1  - Hjorthøj, Carsten
A1  - Krantz, Mette Falkenberg
A1  - Greve, Aja Neergaard
A1  - Bliksted, Vibeke
A1  - Mors, Ole
A1  - Nordentoft, Merete
A1  - Thorup, Anne Amalie Elgaard
A1  - Hemager, Nicoline
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND AND HYPOTHESIS: Suicide is a leading cause of death in youth and is often preceded by suicidal ideation (SI) and non-suicidal self-injury (NSSI). Identifying early markers of risk for SI and NSSI could improve timely identification of at-risk individuals. STUDY DESIGN: Children (mean age 11.9, SD 0.2) at familial high risk of schizophrenia (N = 171), or bipolar disorder (N = 104), and controls (N = 174) were assessed for psychotic experiences (PE), SI, NSSI, and Axis I mental disorders in face-to-face interviews in early and middle childhood (age 7 and 11). STUDY RESULTS: Having 2 types of early childhood PE predicted middle childhood SI after accounting for previous SI, NSSI, and mental disorders (OR 2.8, 95% CI 1.1-6.9; P =.03). Two PE predicted NSSI (OR 3.0, 95% CI 1.2-7.7; P =.02) in excess of previous SI, NSSI, mental disorders, and familial risk. Persistent and incident PE predicted SI (OR 3.2, 95% CI, 1.1-8.8; P =.03; OR 3.8, 95% CI, 1.3-11.5; P =.02) in the fully adjusted model. Nineteen percent of children with persistent PE reported middle childhood SI vs 3.8% of those who never reported PE. In children with early childhood mental disorders, those who reported 2 PE had 4.4-fold increased odds of later SI (95% CI, 1.2-16.7; P =.03) after adjustments. PE were nondifferentially associated with outcomes across familial risk groups. <br><br>CONCLUSIONS: Early childhood PE index elevated risk for subsequent SI and NSSI beyond what can be attributed to presence of mental disorders. Mental health screenings and clinical assessments should include early childhood PE.<p />  <p>Language: en</p>
LA  - en
SN  - 0586-7614
UR  - http://dx.doi.org/10.1093/schbul/sbad052
ID  - ref1
ER  -