TY  - JOUR
PY  - 2023//
TI  - Neurobiological and genetic correlates of the dissociative subtype of posttraumatic stress disorder
JO  - Journal of psychopathology and clinical science
A1  - Wolf, Erika J.
A1  - Hawn, Sage E.
A1  - Sullivan, Danielle R.
A1  - Miller, Mark W.
A1  - Sanborn, Victoria
A1  - Brown, Emma
A1  - Neale, Zoe
A1  - Fein-Schaffer, Dana
A1  - Zhao, Xiang
A1  - Logue, Mark W.
A1  - Fortier, Catherine B.
A1  - McGlinchey, Regina E.
A1  - Milberg, William P.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Approximately 10%-30% of individuals with posttraumatic stress disorder (PTSD) exhibit a dissociative subtype of the condition defined by symptoms of depersonalization and derealization. This study examined the psychometric evidence for the dissociative subtype of PTSD in a sample of young, primarily male post-9/11-era Veterans (n = 374 at baseline and n = 163 at follow-up) and evaluated its biological correlates with respect to resting state functional connectivity (default mode network [DMN]; n = 275), brain morphology (hippocampal subfield volume and cortical thickness; n = 280), neurocognitive functioning (n = 337), and genetic variation (n = 193). Multivariate analyses of PTSD and dissociation items suggested a class structure was superior to dimensional and hybrid ones, with 7.5% of the sample comprising the dissociative class; this group showed stability over 1.5 years. Covarying for age, sex, and PTSD severity, linear regression models revealed that derealization/depersonalization severity was associated with: decreased DMN connectivity between bilateral posterior cingulate cortex and right isthmus (p =.015; adjusted-p [p(adj)] =.097); increased bilateral whole hippocampal, hippocampal head, and molecular layer head volume (p =.010-.034; p(adj) =.032-.053); worse self-monitoring (p =.018; p(adj) =.079); and a candidate genetic variant (rs263232) in the adenylyl cyclase 8 gene (p =.026), previously associated with dissociation. <br><br>RESULTS converged on biological structures and systems implicated in sensory integration, the neural representation of spatial awareness, and stress-related spatial learning and memory, suggesting possible mechanisms underlying the dissociative subtype of PTSD. (PsycInfo Database Record (c) 2023 APA, all rights reserved).<p />  <p>Language: en</p>
LA  - en
SN  - 2769-7541
UR  - http://dx.doi.org/10.1037/abn0000795
ID  - ref1
ER  -