TY  - JOUR
PY  - 2023//
TI  - Longitudinal changes in cortical surface area associated with transition to psychosis in adolescents at clinical high-risk for the disease
JO  - Journal of the American Academy of Child and Adolescent Psychiatry
A1  - Fortea, Adriana
A1  - van Eijndhoven, Philip
A1  - Ilzarbe, Daniel
A1  - Batalla, Albert
A1  - Calvet-Mirabent, Angels
A1  - Serna, Elena de la
A1  - Puig, Olga
A1  - Castro-Fornieles, Josefina
A1  - Dolz, Montserrat
A1  - Tor, Jordina
A1  - Parrilla, Sara
A1  - Via, Esther
A1  - Stephan-Otto, Christian
A1  - Baeza, Inmaculada
A1  - Sugranyes, Gisela
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: Identifying biomarkers of transition to psychosis in individuals at clinical high-risk for psychosis (CHR-P) is essential to understand the mechanisms underlying the disease. Although cross-sectional abnormalities in cortical surface area (CSA) have been demonstrated in individuals at CHR-P who transition to psychosis (CHR-P-T) compared to those who do not (CHR-P-NT), how CSA longitudinally develops remains unclear, especially in younger individuals. We set out to compare CSA in adolescents at CHR-P and healthy controls (HC) over two points in time. <br><br>METHOD: A longitudinal multicenter study was performed in adolescents at CHR-P in comparison to HC and according to transition to psychosis. MRI scans were acquired at baseline, at 18-month follow-up or at the time of transition. Images were pre-processed and hemisphere and regional CSA were computed using FreeSurfer. Between group analyses were performed with linear mixed effects models. <br><br>RESULTS: A total of 313 scans (107 CHR-P and 102 HC) were included in the analysis. At 18 months, rate of transition to psychosis in CHR-P was 23.4%. Adolescents at CHR-P-T presented greater age-related decrease in CSA in the left parietal and occipital lobes compared to HC; and in the bilateral parietal lobe and right frontal lobe relative to CHR-P-NT. These results were not influenced by antipsychotic treatment, cannabis use or intelligence quotient. <br><br>CONCLUSION: Adolescents at CHR-P that developed a psychotic disorder presented different developmental trajectories of CSA relative to those who did not. A relatively greater decrease in CSA in the parietal and frontal lobes may index clinical transition to psychosis in adolescents at CHR-P.<p />  <p>Language: en</p>
LA  - en
SN  - 0890-8567
UR  - http://dx.doi.org/10.1016/j.jaac.2023.01.001
ID  - ref1
ER  -