TY - JOUR PY - 2022// TI - Association between neutrophil levels on admission and all-cause mortality in geriatric patients with hip fractures: a prospective cohort study of 2,589 patients JO - International journal of clinical practice A1 - Liu, Rui A1 - Zhang, Yan-Ning A1 - Fei, Xu-Jing A1 - Wang, Jing-Ya A1 - Hua, Rong-Li A1 - Tong, Ying-Na A1 - Li, Kun A1 - Cao, Wen-Wen A1 - Chen, Shao-Hua A1 - Zhang, Bin-Fei A1 - Chen, Juan A1 - Zhang, Yu-Min SP - e1174521 EP - e1174521 VL - 2022 IS - N2 - OBJECTIVE: To evaluate the association between neutrophil levels and all-cause mortality in geriatric hip fractures.

METHODS: Elderly patients with hip fractures were screened between January 2015 and September 2019. Demographic and clinical characteristics of the patients were collected. Linear and nonlinear multivariate Cox regression models were used to identify the association between neutrophil levels and mortality. Analyses were performed using Empower Stats and R software.

RESULTS: A total of 2,589 patients were included in this study. The mean follow-up period was 38.95 months. During the study period, 875 (33.80%) patients died due to various causes. Linear multivariate Cox regression models showed that neutrophil levels were associated with mortality after adjusting for confounding factors, when neutrophil concentration increased by 1∗10(9)/L, the mortality risk increased by 3% (HR = 1.03, 95% CI: 1.00-1.06, and P=0210). Neutrophil concentration was used as a categorical variable; we only found statistically significant differences when neutrophil levels were high (HR = 1.27, 95% CI:1.05-1.52, and P=0.0122). In addition, the results are stable in P for trend and propensity score matching sensitivity analysis.

CONCLUSIONS: Neutrophil levels are associated with mortality in geriatric hip fractures and could be considered a predictor of death risk in the long-term. This study is registered with the Chinese Clinical Trial Registry (ChiCTR) as number ChiCTR2200057323.

Language: en

LA - en SN - 1368-5031 UR - http://dx.doi.org/10.1155/2022/1174521 ID - ref1 ER -