TY  - JOUR
PY  - 2023//
TI  - Exposures and suspected intoxications to pharmacological and non-pharmacological agents in children aged 0-14 years: real-world data from an Italian reference poison control centre
JO  - Journal of clinical medicine
A1  - Brilli, Valentina
A1  - Crescioli, Giada
A1  - Missanelli, Andrea
A1  - Lanzi, Cecilia
A1  - Trombini, Massimo
A1  - Ieri, Alessandra
A1  - Gambassi, Francesco
A1  - Vannacci, Alfredo
A1  - Mannaioni, Guido
A1  - Lombardi, Niccolò
SP  - e352
EP  - e352
VL  - 12
IS  - 1
N2  - This study describes the exposures and suspected intoxications in children (0-14 years) managed by an Italian reference poison control center (PCC). A seven-year observational retrospective study was performed on the medical records of the Toxicology Unit and PCC, Careggi University Hospital, Florence (Italy). During the study period (2015-2021), a total of 27,212 phone call consultations were managed by the PCC, of which 11,996 (44%) involved subjects aged 0-14 years. Most cases occurred in males (54%) aged 1-5 years (73.8%), mainly at home (97.4%), and with an oral route of intoxication (93%). Cases mainly occurred involuntarily. Consultations were generally requested by caregivers; however, in the age group 12-14 years, 70% were requested by healthcare professionals due to voluntary intoxications. Cleaners (19.44%) and household products (10.90%) were the most represented suspected agents. Pharmacological agents accounted for 28.80% of exposures. Covariates associated with a higher risk of emergency department visit or hospitalization were voluntary intoxication (OR 29.18 [11.76-72.38]), inhalation route (OR 1.87 [1.09-3.23]), and pharmacological agents (OR 1.34 [1.23-1.46]), particularly central nervous system medications. Overall, consultations do not burden national and regional healthcare facilities, revealing the activity of PCCs as having a strategic role in reducing public health spending, even during the COVID-19 pandemic.<p />  <p>Language: en</p>
LA  - en
SN  - 2077-0383
UR  - http://dx.doi.org/10.3390/jcm12010352
ID  - ref1
ER  -