TY  - JOUR
PY  - 2022//
TI  - A genetically informed Registered Report on adverse childhood experiences and mental health
JO  - Nature human behaviour
A1  - Baldwin, Jessie R.
A1  - Sallis, Hannah M.
A1  - Schoeler, Tabea
A1  - Taylor, Mark J.
A1  - Kwong, Alex S. F.
A1  - Tielbeek, Jorim J.
A1  - Barkhuizen, Wikus
A1  - Warrier, Varun
A1  - Howe, Laura D.
A1  - Danese, Andrea
A1  - McCrory, Eamon
A1  - Rijsdijk, Fruhling
A1  - Larsson, Henrik
A1  - Lundström, Sebastian
A1  - Karlsson, Robert
A1  - Lichtenstein, Paul
A1  - Munafó, Marcus
A1  - Pingault, Jean-Baptiste
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene-environment correlations and genetic confounding of the associations between ACEs and mental health. Regarding gene-environment correlations, children with higher polygenic scores for mental health problems had a small increase in odds of ACEs. Regarding genetic confounding, elevated risk of mental health problems in children exposed to ACEs was at least partially due to pre-existing genetic risk. However, some ACEs (such as childhood maltreatment and parental mental illness) remained associated with mental health problems independent of genetic confounding. These findings suggest that interventions addressing heritable psychiatric vulnerabilities in children exposed to ACEs may help reduce their risk of mental health problems.<p />  <p>Language: en</p>
LA  - en
SN  - 2397-3374
UR  - http://dx.doi.org/10.1038/s41562-022-01482-9
ID  - ref1
ER  -