TY  - JOUR
PY  - 2022//
TI  - Comparison of serum and whole blood concentrations in quetiapine overdose cases
JO  - Forensic toxicology
A1  - Saito, Takeshi
A1  - Tsuji, Tomoatsu
A1  - Namera, Akira
A1  - Morita, Seiji
A1  - Nakagawa, Yoshihide
SP  - 403
EP  - 406
VL  - 40
IS  - 2
N2  - This study aimed to compare whole blood and serum concentrations of quetiapine in acute poisoning cases. Authentic whole blood and respective serum samples were routinely collected from patients diagnosed with blood poisoning at our University Hospital. Accordingly, whole blood and serum paired samples from nine patients (one male and eight female patients) were analyzed for quetiapine using liquid chromatography-mass spectrometry (LC-MS). Quetiapine concentrations in whole blood and serum samples ranged widely from 5.4 to 2780 ng/mL and 9.9 to 2500 ng/mL, respectively. The whole blood/serum concentration ratio was 0.5-1.1 and increased together with an increase in whole blood and serum quetiapine concentrations. The ratio was reversed at around 2500 ng/mL to > 1. Our findings suggest that whole blood concentrations are more useful than serum concentrations in diagnosing quetiapine poisonings.<p />  <p>Language: en</p>
LA  - en
SN  - 1860-8965
UR  - http://dx.doi.org/10.1007/s11419-022-00618-w
ID  - ref1
ER  -