TY  - JOUR
PY  - 2022//
TI  - The toxicokinetics of acute paraquat poisoning in specific patients: a case series
JO  - Journal of international medical research
A1  - Shi, Longke
A1  - Yu, Guangcai
A1  - Li, Yaqian
A1  - Zhao, Liwen
A1  - Wen, Zixin
A1  - Tao, Yiming
A1  - Wang, Wenjun
A1  - Jian, Xiangdong
SP  - e3000605221122745
EP  - e3000605221122745
VL  - 50
IS  - 9
N2  - Paraquat is a non-selective contact herbicide that is absorbed through the digestive tract and skin and can cause multiple organ damage. The toxicokinetics of paraquat poisoning in specific patients are rarely reported. Case 1 was a 76-year-old man who intermittently immersed his perineum in diluted paraquat solution for 3 consecutive days because of eczema of the perineal skin. On admission, the patient's scrotal skin was severely corroded and his blood paraquat concentration was 0.5 μg/mL. He developed severe kidney and lung damage after admission and died on Day 6 of admission. Case 2 was a 23-year-old woman who ingested paraquat during gestational week 36. Her initial blood paraquat concentration was 0.81 μg/mL. The patient refused hemoperfusion and a cesarean section. She birthed a baby girl 83 hours after ingesting paraquat. Paraquat concentrations in postnatal maternal blood, fetal blood, umbilical cord blood, and amniotic fluid were 0.19 μg/mL, 0.23 μg/mL, 0.20 μg/mL, and 0.47 μg/mL, respectively. The baby died within hours of birth and the mother died of refractory respiratory failure 2 days after delivery. This paper provides clues about paraquat toxicokinetics in specific patient types and indicates that paraquat can be absorbed through the scrotal skin and the placental barrier.<p />  <p>Language: en</p>
LA  - en
SN  - 0300-0605
UR  - http://dx.doi.org/10.1177/03000605221122745
ID  - ref1
ER  -