TY  - JOUR
PY  - 2022//
TI  - Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: the Danish High Risk and Resilience Study VIA 7
JO  - Social psychiatry and psychiatric epidemiology
A1  - Krantz, Mette Falkenberg
A1  - Hjorthøj, Carsten
A1  - Ellersgaard, Ditte
A1  - Hemager, Nicoline
A1  - Christiani, Camilla
A1  - Spang, Katrine Søborg
A1  - Burton, Birgitte Klee
A1  - Gregersen, Maja
A1  - Søndergaard, Anne
A1  - Greve, Aja
A1  - Ohland, Jessica
A1  - Mortensen, Preben Bo
A1  - Plessen, Kerstin Jessica
A1  - Bliksted, Vibeke
A1  - Jepsen, Jens Richardt Møllegaard
A1  - Thorup, Anne A. E.
A1  - Mors, Ole
A1  - Nordentoft, Merete
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - PURPOSE: Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity. <br><br>METHODS: Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights. <br><br>RESULTS: In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0.04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (p ≤ 0.01 for maternal FHR-SZ and FHR-BP, p = 0.001 for paternal FHR-BP). Inverse probability weighted analyses of results generated from the VIA Study showed minor changes in study findings after adjustment for the found selection bias. <br><br>CONCLUSIONS: Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.<p />  <p>Language: en</p>
LA  - en
SN  - 0933-7954
UR  - http://dx.doi.org/10.1007/s00127-022-02338-3
ID  - ref1
ER  -