TY - JOUR PY - 2022// TI - Association of inflammatory bowel disease with suicidal ideation, suicide attempts, and suicide: a systematic review and meta-analysis JO - Journal of psychosomatic research A1 - Xiong, Qin A1 - Tang, Fuyou A1 - Li, Yilin A1 - Xie, Fengjiao A1 - Yuan, Lei A1 - Yao, Chengjiao A1 - Wu, Ruike A1 - Wang, Juan A1 - Wang, Qiuxiang A1 - Feng, Peimin SP - e110983 EP - e110983 VL - 160 IS - N2 - OBJECTIVE: Inflammatory bowel disease (IBD) is associated with psychiatric comorbidities. However, the association between IBD and suicidal ideation or suicide attempts has not been well established. This study aimed to perform a systematic review and meta-analysis to elucidate the relationship between IBD and suicidal ideation, suicide attempts, and suicide.

METHODS: We systematically searched five electronic databases - PubMed, Embase, CENTRAL, Web of Science, and PsycINFO - from their inception to January 28, 2022. Quality assessment, data synthesis, subgroup analyses, sensitivity analyses, and publication bias assessment were performed on the included studies.

RESULTS: We identified 28 studies with 1,047,755 patients with IBD. The pooled prevalence of suicidal ideation in patients with IBD was 17.3% (95% CI, 9.5%-25.2%). Patients with IBD were associated with an increased risk of suicide attempts (relative risk [RR], 1.39; 95% CI, 1.08-1.79) and suicide deaths (RR, 1.25; 95% CI, 1.09-1.43) than the controls without IBD. Patients with Crohn's disease subtypes, female IBD, pediatric-onset IBD, young adult IBD, and short-duration IBD had a particularly high risk for suicide.

CONCLUSION: Patients with IBD had a high prevalence of suicidal ideation and a significantly higher likelihood of suicide attempts and suicide. Caring for patients with IBD, including their mental health needs, may require concerted efforts among gastroenterologists and other healthcare providers.

Language: en

LA - en SN - 0022-3999 UR - http://dx.doi.org/10.1016/j.jpsychores.2022.110983 ID - ref1 ER -