TY  - JOUR
PY  - 2022//
TI  - Clinical manifestations and serious adverse effects after cannabis use: role of age according to sex and coingestion of alcohol
JO  - Emergencias
A1  - Burillo-Putze, Guillermo
A1  - Ibrahim-Ach, Dima
A1  - Galicia, Miguel
A1  - Supervía, August
A1  - Martínez-Sánchez, Lidia
A1  - Ortega Pérez, Juan
A1  - Matos Castro, Sebastián
A1  - Martín-Pérez, Beatriz
A1  - López Hernández, M. ª Ángeles
A1  - Miró, Òscar
SP  - 275
EP  - 281
VL  - 34
IS  - 4
N2  - OBJECTIVES: To study whether there are age-related differences in the clinical effects of cannabis poisoning and whether any age differences found are also related to sex or coingestion of alcohol.     MATERIAL AND METHODS: Descriptive observational study of patients treated in 11 emergency departments for symptoms related to cannabis use. We collected data on 11 clinical manifestations and used a restricted cubic spline model to analyze their relative frequency according to age. We also looked for any interactions between the findings and patient sex or alcohol coingestion. <br><br>RESULTS: A total of 949 patients were studied. The mean age was 29 years, 74% were males, and 39% had also consumed alcohol. We identified 3 symptom patterns related to age. One set of symptoms (vomiting, headache, convulsions, and hypotension) remained stable across all ages. Manifestations that increased in the middle of the age range studied were agitation and aggressivity, psychosis, palpitations and hallucinations. Chest pain and hypertension increased in older-aged patients. The frequencies of palpitations, vomiting, and headache differed according to sex. These manifestations held constant in males but were markedly higher in young-adult females. Coingestion of alcohol was associated with agitation and aggressivity (in 34.0% vs 23.4%, P.001), fewer reports of palpitations (in 9.8% vs 15.6%, P =.01), less anxiety (in 20.7% vs 27.8%, P =.01), less psychosis (in 10.3% vs 16.6%, P =.007), and less chest pain (in 3.8% vs 9.5%, P =.001). The only significant interaction between age and alcohol coingestion occurred with respect to vomiting and psychosis. <br><br>CONCLUSION: There are age-related differences in the acute clinical manifestations of cannabis poisoning requiring emergency hospital care. Sex and coingestion of alcohol modify the relationship between age and frequency of some manifestations.<p />  <p>Language: en</p>
LA  - en
SN  - 1137-6821
UR  - http://dx.doi.org/
ID  - ref1
ER  -