TY  - JOUR
PY  - 2022//
TI  - Corneal toxicity after stinging by a sea anemone, Anthopleura uchidai: a case report with confirmation by in vitro study
JO  - Cornea
A1  - Ono, Takashi
A1  - Iwasaki, Takuya
A1  - Terada, Yukiko
A1  - Miyai, Takashi
A1  - Mori, Yosai
A1  - Nejima, Ryohei
A1  - Honma, Tomohiro
A1  - Aihara, Makoto
A1  - Miyata, Kazunori
SP  - 1035
EP  - 1037
VL  - 41
IS  - 8
N2  - PURPOSE: This study aimed to present a case of transient corneal damage after exposure to the effluent squirting from a sea anemone, Anthopleura uchidai, and to experimentally confirm the presence of toxic substances from an A. uchidai in the tissue culture. <br><br>METHODS: We reviewed the clinical course of a 51-year-old man who complained of decreased vision in his left eye after the stinging of a sea anemone, A. uchidai. The toxicity of the effluents from an A. uchidai in immortalized human corneal endothelial cells (HCEnC-21T) and human corneal epithelial cells in vitro were evaluated. <br><br>RESULTS: Corneal edema was observed, and his best-corrected visual acuity was 0.2. Corneal endothelial cell density decreased to 1435 cells/mm2. Although his corneal edema and visual acuity recovered after topical instillation with a topical steroid and 5% NaCl, corneal endothelial cell density did not recover for 3 years after the injury. The in vitro study revealed fractioned effluence from the sea anemone, by size-exclusion chromatography, containing a substance toxic to HCEnC-21T with cytoplasmic swelling and nuclear dislocation. <br><br>CONCLUSIONS: It is necessary to be cautious of effluents from sea anemones along the coast, and ophthalmologists should be aware that sea anemones can cause corneal endothelial dysfunction.<p />  <p>Language: en</p>
LA  - en
SN  - 0277-3740
UR  - http://dx.doi.org/10.1097/ICO.0000000000002842
ID  - ref1
ER  -