TY  - JOUR
PY  - 2022//
TI  - Fatal rectal injection of 3-MMC in a sexual context. toxicological investigations including metabolites identification using LC-HRMS
JO  - Journal of analytical toxicology
A1  - Aknouche, Frédéric
A1  - Ameline, Alice
A1  - Gheddar, Laurie
A1  - Maruejouls, Christophe
A1  - Kintz, Pascal
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - [3 Methylmethcathinone, also known as 3-MMC and metaphedrone,[2] is a designer drug from the substituted cathinone family. 3-MMC is closely related in structure to the more commonly known illicit drug mephedrone (4-MMC), and is also illegal in most countries that have banned mephedrone due to 3-MMC being a structural isomer of 4-MMC. However, 3-MMC has still appeared on the recreational drug market as an alternative to mephedrone. - Wikipedia]    The dead body of a 59-year-old man was found at his home by his father. The subject was naked in the corridor, wearing a black hood and a collar around the neck where a dog leash was attached. An empty syringe was discovered in the decedent's rectal vein. The autopsy revealed marked asphyxia signs with no indication of violence or trauma. Femoral blood, urine and hair (4 cm, brown) were collected and submitted for comprehensive toxicological investigation. Initial screening did not indicate the presence of ethanol or any other over-the-counter or prescription pharmaceuticals. Routine toxicology screening by liquid chromatography-tandem mass spectrometry (LC-MS-MS) tentatively identified only the cathinone stereoisomer(s), 3-methylmethcathinone (3-MMC) or mephedrone (4-MMC). Analysis by GC-MS to distinguish between the isomers revealed the presence of 3-MMC, which was subsequently quantified by LC-MS-MS. Femoral blood and urine concentrations were 1437 ng/mL and 16733 ng/mL, respectively. In 4 x 1 cm hair segments, 3-MMC was detected at less than 10 pg/mg (LOQ). Further analysis by high-resolution mass spectrometry (LC-HRMS) allowed identification of two metabolites in both blood and urine: desmethyl-3-MMC and hydroxyl-3-MMC. The pathologist established the cause of death in this case as acute 3-MMC poisoning in the context of ChemSex.<p />  <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/10.1093/jat/bkac048
ID  - ref1
ER  -