TY  - JOUR
PY  - 2022//
TI  - Association between timing of epinephrine administration and outcomes of traumatic out-of-hospital cardiac arrest following traffic collisions
JO  - Journal of clinical medicine
A1  - Hosomi, Sanae
A1  - Kitamura, Tetsuhisa
A1  - Sobue, Tomotaka
A1  - Zha, Ling
A1  - Kiyohara, Kosuke
A1  - Matsuyama, Tasuku
A1  - Oda, Jun
SP  - e3564
EP  - e3564
VL  - 11
IS  - 12
N2  - The effects of epinephrine administration timing on patients with out-of-hospital cardiac arrest (OHCA) following traffic collisions are unknown. We analyzed the 2013-2019 All-Japan Utstein Registry data of 2024 such patients aged ≥18 years who were resuscitated by emergency medical service (EMS) personnel or bystanders and then transported to medical institutions. Time from 119 call to epinephrine administration was classified into quartiles: Q1 (6-21 min), Q2 (22-26 min), Q3 (27-34 min), and Q4 (35-60 min). Multivariable logistic regression analysis was used to assess the effects of epinephrine administration timing on one-month survival after OHCA. Overall, the one-month survival rates were 3.2% (15/466) in Q1, 1.1% (5/472) in Q2, 1.9% (11/577) in Q3, and 0.2% (1/509) in Q4. Additionally, the one-month survival rate decreased significantly in the Q4 group (adjusted odds ratio, 0.07; 95% confidence interval, 0.01-0.57) compared with the Q1 group, and the probability of one-month survival decreased as the time from the EMS call to epinephrine administration increased (p-value for trend = 0.009). Only four patients (0.9% [4/466]) with the earliest epinephrine administration showed a good neurological outcome.<p />  <p>Language: en</p>
LA  - en
SN  - 2077-0383
UR  - http://dx.doi.org/10.3390/jcm11123564
ID  - ref1
ER  -