TY  - JOUR
PY  - 2022//
TI  - Falls in Parkinson's disease: the impact of disease progression, treatment, and motor complications
JO  - Dementia and neuropsychologia
A1  - Lima, Danielle Pessoa
A1  - de-Almeida, Samuel Brito
A1  - Bonfadini, Janine de Carvalho
A1  - Carneiro, Alexandre Henrique Silva
A1  - de Luna, João Rafael Gomes
A1  - de Alencar, Madeleine Sales
A1  - Viana-Júnior, Antonio Brazil
A1  - Rodrigues, Pedro Gustavo Barros
A1  - Pereira, Isabelle de Sousa
A1  - Roriz-Filho, Jarbas de Sá
A1  - Sobreira-Neto, Manoel Alves
A1  - Braga-Neto, Pedro
SP  - 153
EP  - 161
VL  - 16
IS  - 2
N2  - The prevalence of Parkinson's disease (PD) tends to increase worldwide in the coming decades. Thus, the incidence of falls is likely to increase, with a relevant burden on the health care system. <br><br>OBJECTIVE: The objective of this study was to evaluate clinical factors and drug use associated with falls in PD patients. <br><br>METHODS: We conducted a cross-sectional study at the Movement Disorders outpatient clinic of a tertiary hospital in Northeast Brazil. We performed structured interviews to collect sociodemographic and clinical data. Functional capacity was assessed using the Schwab and England Activities of Daily Living Scale and the modified Hoehn and Yahr Staging Scale. We divided the study sample into non-fallers (no falls) and fallers (≥1 fall), and non-recurrent (≤1 fall) and recurrent fallers (>1 fall). <br><br>RESULTS: The study population comprised 327 PD patients (48% women), with a mean age of 70 years. The mean disease duration was 9.9±6.9 years. The most prevalent comorbidities were depression (47.2%), hypertension (44.0%), and type 2 diabetes mellitus (21.5%). The logistic regression analysis revealed that hallucinations, amantadine, and catechol-O-methyltransferase inhibitors (entacapone) were independently associated with falls in PD patients. Also, hallucinations, dyskinesia, and the use of amantadine were independently associated with recurrent falls. <br><br>CONCLUSIONS: Health care providers play an essential role in fall prevention in PD patients, particularly by identifying older adults experiencing dyskinesia and visual hallucinations. Prospective studies should investigate the use of amantadine as a risk factor for falls in PD patients.<p />  <p>Language: en</p>
LA  - en
SN  - 1980-5764
UR  - http://dx.doi.org/10.1590/1980-5764-DN-2021-0019
ID  - ref1
ER  -