TY  - JOUR
PY  - 2022//
TI  - The geometry of domain-general performance monitoring in the human medial frontal cortex
JO  - Science
A1  - Fu, Zhongzheng
A1  - Beam, Danielle
A1  - Chung, Jeffrey M.
A1  - Reed, Chrystal M.
A1  - Mamelak, Adam N.
A1  - Adolphs, Ralph
A1  - Rutishauser, Ueli
SP  - eabm9922
EP  - eabm9922
VL  - 376
IS  - 6593
N2  - What are the neural mechanisms that enable humans to flexibly control and monitor their own actions in various non-routine and novel tasks? Fu et al. recorded the activity of more than 1000 neurons in the medial frontal cortex of human epilepsy patients while they performed complex cognitive tasks. They found that domain-general and domain-specific performance monitoring neurons were intermixed within this brain region. The population activity gave rise to a geometry that allowed domain-general signals to be read out with more than 90% accuracy on single trials while at the same time retaining the ability to separate different conflict conditions. These results show how the human medial frontal cortex resolves the fundamental trade-off between task generalization and specialization, which is critical for cognitive flexibility<p />
LA  - en
SN  - 0036-8075
UR  - http://dx.doi.org/10.1126/science.abm9922
ID  - ref1
ER  -