TY  - JOUR
PY  - 2022//
TI  - Effects of low-intensity vestibular noise stimulation on postural instability in patients with Parkinson's disease
JO  - Journal of Parkinson's disease
A1  - Wuehr, Max
A1  - Schmidmeier, Florian
A1  - Katzdobler, Sabrina
A1  - Fietzek, Urban M.
A1  - Levin, Johannes
A1  - Zwergal, Andreas
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Postural instability is a major disabling factor in patients with advanced Parkinson's disease (PD) and often resistant to treatment. Previous studies indicated that imbalance in PD may be reduced by low-intensity noisy galvanic vestibular stimulation (nGVS). <br><br>OBJECTIVE: To investigate the potential mode of action of this therapeutic effect. In particular, we examined whether nGVS-induced reductions of body sway in PD are compatible with stochastic resonance (SR), a mechanism by which weak sensory noise stimulation can paradoxically enhance sensory information transfer. <br><br>METHODS: Effects of nGVS of varying intensities (0-0.7 mA) on body sway were examined in 15 patients with PD standing with eye closed on a posturographic force plate. We assumed a bell-shaped response curve with maximal reductions of sway at intermediate nGVS intensities to be indicative of SR. An established SR-curve model was fitted on individual patient outcomes and three experienced human raters had to judge whether responses to nGVS were consistent with the exhibition of SR. <br><br>RESULTS: nGVS-induced reductions of body sway compatible with SR were found in 10 patients (67%) with optimal improvements of 23±13%. In 7 patients (47% ), nGVS-induced sway reductions exceeded the minimally important clinical difference (optimal improvement: 30±10% ), indicative of strong SR. This beneficial effect was more likely in patients with advanced PD (R = 0.45; p = 0.045). <br><br>CONCLUSIONS: At least half of the assessed patients showed robust improvements in postural balance compatible with SR when treated with low-intensity nGVS. In particular, patients with more advanced disease stages and imbalance may benefit from the non-invasive and well-tolerated treatment with nGVS.<p />  <p>Language: en</p>
LA  - en
SN  - 1877-7171
UR  - http://dx.doi.org/10.3233/JPD-213127
ID  - ref1
ER  -