TY  - JOUR
PY  - 2022//
TI  - Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
JO  - Acta bio-medica de l'ateneo Parmense
A1  - Marchese, Pietro
A1  - Lardone, Chiara
A1  - Canepele, Alessia
A1  - Biondi, Samanta
A1  - Roggi, Costantino
A1  - Massart, Francesco
A1  - Bonuccelli, Alice
A1  - Peroni, Diego
A1  - Giotta Lucifero, Alice
A1  - Luzzi, Sabino
A1  - Foiadelli, Thomas
A1  - Orsini, Alessandro
SP  - e2021417
EP  - e2021417
VL  - 92
IS  - S4
N2  - Leading causes of death in industrialized countries are traumatic injuries and acquired disability, and entry to the emergency department in childhood. TBI (traumatic brain injury) may involve the onset of both primary lesions and a complex immune response (sterile immune reaction to brain injury), which, in addition to neuro-protective effects, can mediate secondary neurological injury. The neutrophil-to-lymphocyte ratio (NLR), as a circulating inflammatory marker, has been related to outcomes in adult patients with non-neurologic diseases (such as gut tumours) or neurologic diseases (such as stroke or brain tumours), and to the prognosis of traumatic brain injury in adolescents and adults. However, the potential role of NLR in predicting outcomes in paediatric head trauma is not clearly defined. The aim of this retrospective observational study is to evaluate the association between clinical features predictive of intracranial and extracranial lesions in TBI and NLR and to establish whether an elevation of NLR is indirectly associated with adverse outcomes in pediatric patients with TBI. We analysed a sample of 219 pediatric patients, between 2-18 years old, after a TBI, and evaluated if differences in NLR were associated with neurological signs or positive CT in pediatric patients. We then compared the NLR values ​​between healthy subjects and patients with TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0392-4203
UR  - http://dx.doi.org/10.23750/abm.v92iS4.12666
ID  - ref1
ER  -