TY  - JOUR
PY  - 2022//
TI  - Neuroinflammation following traumatic brain injury: take it seriously or not
JO  - Frontiers in immunology
A1  - Zheng, Rui-Zhe
A1  - Lee, Kuin-Yu
A1  - Qi, Zeng-Xin
A1  - Wang, Zhe
A1  - Xu, Ze-Yu
A1  - Wu, Xue-Hai
A1  - Mao, Ying
SP  - e855701
EP  - e855701
VL  - 13
IS  - 
N2  - Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial socioeconomic burden. With the standardization of the treatment process, there is increasing interest in the role that the secondary insult of TBI plays in outcome heterogeneity. The secondary insult is neither detrimental nor beneficial in an absolute sense, among which the inflammatory response was a complex cascade of events and can thus be regarded as a double-edged sword. Therefore, clinicians should take the generation and balance of neuroinflammation following TBI seriously. In this review, we summarize the current human and animal model studies of neuroinflammation and provide a better understanding of the inflammatory response in the different stages of TBI. In particular, advances in neuroinflammation using proteomic and transcriptomic techniques have enabled us to identify a functional specific delineation of the immune cell in TBI patients. Based on recent advances in our understanding of immune cell activation, we present the difference between diffuse axonal injury and focal brain injury. In addition, we give a figurative profiling of the general paradigm in the pre- and post-injury inflammatory settings employing a bow-tie framework.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-3224
UR  - http://dx.doi.org/10.3389/fimmu.2022.855701
ID  - ref1
ER  -