TY  - JOUR
PY  - 2022//
TI  - Association of atopic dermatitis with depression and suicide: a two-sample Mendelian randomization study
JO  - BioMed research international
A1  - Qi, Hong-Jiao
A1  - Li, Lin-Feng
SP  - e4084121
EP  - e4084121
VL  - 2022
IS  - 
N2  - BACKGROUND: Atopic dermatitis (AD) has long been hypothesized to be associated with risk of depression and suicide, but the causal relationship between them is still unclear. <br><br>OBJECTIVE: To evaluate the causality between AD, depression, and suicide using a Mendelian randomization (MR) approach. <br><br>METHOD: We extracted summary-level data for AD, major depression, and suicidal ideation or attempt from published, nonoverlapping genome-wide association studies (GWAS). Inverse variance-weighted (IVW) analysis was used as the primary analysis. Alternate methods, including weighted median, MR Egger, MR pleiotropy residual sum and outlier, weighted mode, and leave-out analysis, were performed to assess pleiotropy. <br><br>RESULTS: 13 SNPs (13,287 cases and 41,345 controls) were selected as instrumental variables (IVs). The IVW analysis indicated a statistically significant but small causal effect of AD on major depression (OR = 1.027, 95% CI 1.004-1.050; p = 0.020). No significant evidence was observed for a causal effect of AD on suicide. No significant effect of pleiotropy was found. <br><br>CONCLUSION: AD has a significant but small effect on major depression, but not on suicide.<p />  <p>Language: en</p>
LA  - en
SN  - 2314-6133
UR  - http://dx.doi.org/10.1155/2022/4084121
ID  - ref1
ER  -