TY  - JOUR
PY  - 2022//
TI  - Neural substrates of rewarding and punishing self representations in depressed suicide-attempting adolescents
JO  - Journal of psychiatric research
A1  - Quevedo, Karina
A1  - Teoh, Jia Yuan
A1  - Liu, Guanmin
A1  - Santana-Gonzalez, Carmen
A1  - Forbes, Erika E.
A1  - Engstrom, Maggie
SP  - 204
EP  - 213
VL  - 148
IS  - 
N2  - Adolescence is a period of plasticity in neural substrates underpinning self-processing. Such substrates are worth studying in depressed youth at risks for suicide because altered neurobiology of self-processing might partially explain differences between suicide attempting youth versus youth who contemplate but do not attempt suicide. Understanding altered substrates of self-processing among depressed adolescents with suicide attempts is critical for developing targeted prevention and treatment. Healthy youth (N = 40), youth with depression and low (N = 33) or high suicide ideation (N = 28), and youth with depression and past suicide attempt (N = 28) heard positive or negative self-descriptors during fMRI and evaluated them from their own, their mother's, classmates', and best friend's perspectives. Lower bilateral caudate activity during positive self-processing distinguished suicide attempting adolescents from all other youth. Higher bilateral caudate activity during negatively valenced self-processing tended to distinguish youth with depression. Blunted reward circuitry during positive vs. negative self-related material tended to distinguish suicide attempting youth, reflecting potentially enhanced behavioral preparedness for punishing vs. rewarding self-relevant cues.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2022.01.037
ID  - ref1
ER  -