TY  - JOUR
PY  - 2022//
TI  - Advanced brain age in deployment-related traumatic brain injury: a LIMBIC-CENC neuroimaging study
JO  - Brain injury
A1  - Dennis, Emily L.
A1  - Taylor, Brian A.
A1  - Newsome, Mary R.
A1  - Troyanskaya, Maya
A1  - Abildskov, Tracy J.
A1  - Betts, Aaron M.
A1  - Bigler, Erin D.
A1  - Cole, James
A1  - Davenport, Nicholas
A1  - Duncan, Timothy
A1  - Gill, Jessica
A1  - Guedes, Vivian
A1  - Hinds, Sidney R. 2nd
A1  - Hovenden, Elizabeth S.
A1  - Kenney, Kimbra
A1  - Pugh, Mary Jo
A1  - Scheibel, Randall S.
A1  - Shahim, Pashtun-Poh
A1  - Shih, Robert
A1  - Walker, William C.
A1  - Werner, J. Kent
A1  - York, Gerald E.
A1  - Cifu, David X.
A1  - Tate, David F.
A1  - Wilde, Elisabeth A.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: To determine if history of mild traumatic brain injury (mTBI) is associated with advanced or accelerated brain aging among the United States (US) military Service Members and Veterans. <br><br>METHODS: Eight hundred and twenty-two participants (mean age = 40.4 years, 714 male/108 female) underwent MRI sessions at eight sites across the US. Two hundred and one participants completed a follow-up scan between five months and four years later. Predicted brain ages were calculated using T1-weighted MRIs and then compared with chronological ages to generate an Age Deviation Score for cross-sectional analyses and an Interval Deviation Score for longitudinal analyses. Participants also completed a neuropsychological battery, including measures of both cognitive functioning and psychological health. <br><br>RESULT: In cross-sectional analyses, males with a history of deployment-related mTBI showed advanced brain age compared to those without (t(884) = 2.1, p = .038), while this association was not significant in females. In follow-up analyses of the male participants, severity of posttraumatic stress disorder (PTSD), depression symptoms, and alcohol misuse were also associated with advanced brain age. <br><br>CONCLUSION: History of deployment-related mTBI, severity of PTSD and depression symptoms, and alcohol misuse are associated with advanced brain aging in male US military Service Members and Veterans.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-9052
UR  - http://dx.doi.org/10.1080/02699052.2022.2033844
ID  - ref1
ER  -