TY  - JOUR
PY  - 2022//
TI  - Risk of self-harm or suicide associated with specific drug use disorders, 2004-2016: a population-based cohort study
JO  - Addiction
A1  - Chai, Yi
A1  - Luo, Hao
A1  - Wei, Yue
A1  - Chan, Sherry K. W.
A1  - Man, Kenneth K. C.
A1  - Yip, Paul S. F.
A1  - Wong, Ian C. K.
A1  - Chan, Esther W.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND AND AIMS: Drug use disorders are associated with increased risk of self-harm. Risk differences associated with specific types of drug use disorders are yet to be comprehensively reported. This study aimed to examine the risk of self-harm or suicide associated with different drug use disorders in Hong Kong. <br><br>DESIGN: Population-based cohort study. SETTING: The Clinical Data Analysis & Reporting System (CDARS) managed by the Hong Kong Hospital Authority. PARTICIPANTS: Cases were people aged 10 years or older who visited a hospital Accident & Emergency department between January 1, 2004 and December 31, 2016 with any of ten specific drug use disorders (comprising opioid; ketamine; methamphetamine; sedative, hypnotic, or anxiolytic; amphetamine or related stimulant; cocaine; cannabis; hallucinogen; unspecified or other drug; and polydrug). Each case was matched with two controls, selected from a subset of people in CDARS sharing the same gender, age, and psychiatric profile. A total of 8,270 cases and 16,540 matched controls were included. MEASUREMENTS: Incidence and adjusted hazard ratio (aHR) of subsequent self-harm or suicide for each specific drug use disorder were estimated. <br><br>FINDINGS: The most prevalent drug use disorder was opioid use disorder (2,523; 30.51%) and the least prevalent was hallucinogen use disorder (77; 0.93%). The crude incidence of self-harm or suicide ranged from 26.57 (95% confidence interval [CI], 14.23-44.55) per 1000 person-years for cannabis use disorder to 91.97 (77.32-108.37) for polydrug use disorder. The highest risk of self-harm or suicide was observed in ketamine (aHR, 16.36; 95% CI, 11.03-24.29) and opioid (15.97; 10.73-23.23) use disorders. <br><br>CONCLUSIONS: In Hong Kong, all types of drug use disorders appear to be significantly associated with increased risk of self-harm or suicide, but risk levels vary by type of drug use disorder.<p />  <p>Language: en</p>
LA  - en
SN  - 0965-2140
UR  - http://dx.doi.org/10.1111/add.15820
ID  - ref1
ER  -