TY  - JOUR
PY  - 2022//
TI  - Enduring effect of abuse: childhood maltreatment links to altered theory of mind network among adults
JO  - Human brain mapping
A1  - Pang, Yajing
A1  - Zhao, Shanshan
A1  - Li, Zhihui
A1  - Li, Nan
A1  - Yu, Jiarui
A1  - Zhang, Rui
A1  - Lu, Fengmei
A1  - Chen, Heng
A1  - Wu, Fengchun
A1  - Zheng, Wei
A1  - Gao, Jingjing
A1  - Yang, Yongfeng
A1  - Wu, Huawang
A1  - Wang, Jiaojian
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Childhood maltreatment (CM) confers a great risk of maladaptive development outcomes later in life, however, the neurobiological mechanism underlying this vulnerability is still unclear. The present study aimed to investigate the long-term consequences of CM on neural connectivity while controlling for psychiatric conditions, medication, and, substance abuse. A sample including adults with (n = 40) and without CM (n = 50) completed Childhood Trauma Questionnaire (CTQ), personality questionnaires, and resting-state functional magnetic resonance imaging scan were recruited for the current study. The whole-brain functional connectivity (FC) was evaluated using an unbiased, data-driven, multivariate pattern analysis method. Relative to controls, adults with CM suffered a higher level of temperament and impulsivity and showed decreased FC between the insula and superior temporal gyrus (STG) and between inferior parietal lobule (IPL) and middle frontal gyrus, STG, and dorsal anterior cingulate cortex (dACC), while increased FC between IPL and cuneus and superior frontal gyrus (SFG) regions. The FCs of IPL with dACC and SFG were correlated with the anxious and cyclothymic temperament and attentional impulsivity. Moreover, these FCs partially mediated the relationship between CM and attentional impulsivity. Our results suggest that CM has a significant effect on the modulation of FC within theory of mind (ToM) network even decades later in adulthood, and inform a new framework to account for how CM results in the development of impulsivity. The novel findings reveal the neurobiological consequences of CM and provide new clues to the prevention and intervention strategy to reduce the risk of the development of psychopathology.<p />  <p>Language: en</p>
LA  - en
SN  - 1065-9471
UR  - http://dx.doi.org/10.1002/hbm.25787
ID  - ref1
ER  -