TY  - JOUR
PY  - 2021//
TI  - A preliminary model of football-related neural stress that integrates metabolomics with transcriptomics and virtual reality
JO  - iScience
A1  - Vike, Nicole L.
A1  - Bari, Sumra
A1  - Stetsiv, Khrystyna
A1  - Walter, Alexa
A1  - Newman, Sharlene
A1  - Kawata, Keisuke
A1  - Bazarian, Jeffrey J.
A1  - Martinovich, Zoran
A1  - Nauman, Eric A.
A1  - Talavage, Thomas M.
A1  - Papa, Linda
A1  - Slobounov, Semyon M.
A1  - Breiter, Hans C.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Research suggests contact sports affect neurological health. This study used permutation-based mediation statistics to integrate measures of metabolomics, neuroinflammatory miRNAs, and virtual reality (VR)-based motor control to investigate multi-scale relationships across a season of collegiate American football. Fourteen significant mediations (six pre-season, eight across-season) were observed where metabolites always mediated the statistical relationship between miRNAs and VR-based motor control (ppermSobel ≤ 0.05; total effect > 50%), suggesting a hypothesis that metabolites sit in the statistical pathway between transcriptome and behavior. Three results further supported a model of chronic neuroinflammation, consistent with mitochondrial dysfunction: (1) Mediating metabolites were consistently medium-to-long chain fatty acids, (2) tricarboxylic acid cycle metabolites decreased across-season, and (3) accumulated head acceleration events statistically moderated pre-season metabolite levels to directionally model post-season metabolite levels. These preliminary findings implicate potential mitochondrial dysfunction and highlight probable peripheral blood biomarkers underlying repetitive head impacts in otherwise healthy collegiate football athletes.<p />  <p>Language: en</p>
LA  - en
SN  - 2589-0042
UR  - http://dx.doi.org/10.1016/j.isci.2021.103483
ID  - ref1
ER  -