TY  - JOUR
PY  - 2021//
TI  - Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors
JO  - Biological psychiatry
A1  - Mullins, Niamh
A1  - Kang, JooEun
A1  - Campos, Adrian I.
A1  - Coleman, Jonathan R. I.
A1  - Edwards, Alexis C.
A1  - Galfalvy, Hanga
A1  - Levey, Daniel F.
A1  - Lori, Adriana
A1  - Shabalin, Andrey
A1  - Starnawska, Anna
A1  - Su, Mei-Hsin
A1  - Watson, Hunna J.
A1  - Adams, Mark
A1  - Awasthi, Swapnil
A1  - Gandal, Michael
A1  - Hafferty, Jonathan D.
A1  - Hishimoto, Akitoyo
A1  - Kim, Minsoo
A1  - Okazaki, Satoshi
A1  - Otsuka, Ikuo
A1  - Ripke, Stephan
A1  - Ware, Erin B.
A1  - Bergen, Andrew W.
A1  - Berrettini, Wade H.
A1  - Bohus, Martin
A1  - Brandt, Harry
A1  - Chang, Xiao
A1  - Chen, Wei J.
A1  - Chen, Hsi-Chung
A1  - Crawford, Steven
A1  - Crow, Scott
A1  - DiBlasi, Emily
A1  - Duriez, Philibert
A1  - Fernández-Aranda, Fernando
A1  - Fichter, Manfred M.
A1  - Gallinger, Steven
A1  - Glatt, Stephen J.
A1  - Gorwood, Philip
A1  - Guo, Yiran
A1  - Hakonarson, Hakon
A1  - Halmi, Katherine A.
A1  - Hwu, Hai-Gwo
A1  - Jain, Sonia
A1  - Jamain, Stéphane
A1  - Jimenez-Murcia, Susana
A1  - Johnson, Craig
A1  - Kaplan, Allan S.
A1  - Kaye, Walter H.
A1  - Keel, Pamela K.
A1  - Kennedy, James L.
A1  - Klump, Kelly L.
A1  - Li, Dong
A1  - Liao, Shih-Cheng
A1  - Lieb, Klaus
A1  - Lilenfeld, Lisa
A1  - Liu, Chih-Min
A1  - Magistretti, Pierre J.
A1  - Marshall, Christian R.
A1  - Mitchell, James E.
A1  - Monson, Eric T.
A1  - Myers, Richard M.
A1  - Pinto, Dalila
A1  - Powers, Abigail
A1  - Ramoz, Nicolas
A1  - Roepke, Stefan
A1  - Rozanov, Vsevolod A.
A1  - Scherer, Stephen W.
A1  - Schmahl, Christian
A1  - Sokolowski, Marcus
A1  - Strober, Michael
A1  - Thornton, Laura M.
A1  - Treasure, Janet
A1  - Tsuang, Ming T.
A1  - Witt, Stephanie H.
A1  - Woodside, D. Blake
A1  - Yilmaz, Zeynep
A1  - Zillich, Lea
A1  - Adolfsson, Rolf
A1  - Agartz, Ingrid
A1  - Air, Tracy M.
A1  - Alda, Martin
A1  - Alfredsson, Lars
A1  - Andreassen, Ole A.
A1  - Anjorin, Adebayo
A1  - Appadurai, Vivek
A1  - Soler Artigas, María
A1  - Van der Auwera, Sandra
A1  - Azevedo, M. Helena
A1  - Bass, Nicholas
A1  - Bau, Claiton H. D.
A1  - Baune, Bernhard T.
A1  - Bellivier, Frank
A1  - Berger, Klaus
A1  - Biernacka, Joanna M.
A1  - Bigdeli, Tim B.
A1  - Binder, Elisabeth B.
A1  - Boehnke, Michael
A1  - Boks, Marco P. M.
A1  - Bosch, Rosa
A1  - Braff, David L.
A1  - Bryant, Richard
A1  - Budde, Monika
A1  - Byrne, Enda M.
A1  - Cahn, Wiepke
A1  - Casas, Miguel
A1  - Castelao, Enrique
A1  - Cervilla, Jorge A.
A1  - Chaumette, Boris
A1  - Cichon, Sven
A1  - Corvin, Aiden
A1  - Craddock, Nicholas
A1  - Craig, David
A1  - Degenhardt, Franziska
A1  - Djurovic, Srdjan
A1  - Edenberg, Howard J.
A1  - Fanous, Ayman H.
A1  - Foo, Jerome C.
A1  - Forstner, Andreas J.
A1  - Frye, Mark
A1  - Fullerton, Janice M.
A1  - Gatt, Justine M.
A1  - Gejman, Pablo V.
A1  - Giegling, Ina
A1  - Grabe, Hans J.
A1  - Green, Melissa J.
A1  - Grevet, Eugenio H.
A1  - Grigoroiu-Serbanescu, Maria
A1  - Gutiérrez, Blanca
A1  - Guzman-Parra, Jose
A1  - Hamilton, Steven P.
A1  - Hamshere, Marian L.
A1  - Hartmann, Annette
A1  - Hauser, Joanna
A1  - Heilmann-Heimbach, Stefanie
A1  - Hoffmann, Per
A1  - Ising, Marcus
A1  - Jones, Ian
A1  - Jones, Lisa A.
A1  - Jonsson, Lina
A1  - Kahn, Rene S.
A1  - Kelsoe, John R.
A1  - Kendler, Kenneth S.
A1  - Kloiber, Stefan
A1  - Koenen, Karestan C.
A1  - Kogevinas, Manolis
A1  - Konte, Bettina
A1  - Krebs, Marie-Odile
A1  - Landén, Mikael
A1  - Lawrence, Jacob
A1  - Leboyer, Marion
A1  - Lee, Phil H.
A1  - Levinson, Douglas F.
A1  - Liao, Calwing
A1  - Lissowska, Jolanta
A1  - Lucae, Susanne
A1  - Mayoral, Fermín
A1  - McElroy, Susan L.
A1  - McGrath, Patrick
A1  - McGuffin, Peter
A1  - McQuillin, Andrew
A1  - Medland, Sarah E.
A1  - Mehta, Divya
A1  - Melle, Ingrid
A1  - Milaneschi, Yuri
A1  - Mitchell, Philip B.
A1  - Molina, Esther
A1  - Morken, Gunnar
A1  - Mortensen, Preben Bo
A1  - Müller-Myhsok, Bertram
A1  - Nievergelt, Caroline
A1  - Nimgaonkar, Vishwajit
A1  - Nothen, Markus M.
A1  - O'Donovan, Michael C.
A1  - Ophoff, Roel A.
A1  - Owen, Michael J.
A1  - Pato, Carlos
A1  - Pato, Michele T.
A1  - Penninx, Brenda W. J. H.
A1  - Pimm, Jonathan
A1  - Pistis, Giorgio
A1  - Potash, James B.
A1  - Power, Robert A.
A1  - Preisig, Martin
A1  - Quested, Digby
A1  - Ramos-Quiroga, Josep Antoni
A1  - Reif, Andreas
A1  - Ribasés, Marta
A1  - Richarte, Vanesa
A1  - Rietschel, Marcella
A1  - Rivera, Margarita
A1  - Roberts, Andrea
A1  - Roberts, Gloria
A1  - Rouleau, Guy A.
A1  - Rovaris, Diego Luiz
A1  - Rujescu, Dan
A1  - Sánchez-Mora, Cristina
A1  - Sanders, Alan R.
A1  - Schofield, Peter R.
A1  - Schulze, Thomas G.
A1  - Scott, Laura J.
A1  - Serretti, Alessandro
A1  - Shi, Jianxin
A1  - Shyn, Stanley I.
A1  - Sirignano, Lea
A1  - Sklar, Pamela
A1  - Smeland, Olav B.
A1  - Smoller, Jordan W.
A1  - Sonuga-Barke, Edmund J. S.
A1  - Spalletta, Gianfranco
A1  - Strauss, John S.
A1  - Świątkowska, Beata
A1  - Trzaskowski, Maciej
A1  - Turecki, Gustavo
A1  - Vilar-Ribó, Laura
A1  - Vincent, John B.
A1  - Völzke, Henry
A1  - Walters, James T. R.
A1  - Shannon Weickert, Cynthia
A1  - Weickert, Thomas W.
A1  - Weissman, Myrna M.
A1  - Williams, Leanne M.
A1  - Wray, Naomi R.
A1  - Zai, Clement C.
A1  - Ashley-Koch, Allison E.
A1  - Beckham, Jean C.
A1  - Hauser, Elizabeth R.
A1  - Hauser, Michael A.
A1  - Kimbrel, Nathan A.
A1  - Lindquist, Jennifer H.
A1  - McMahon, Benjamin
A1  - Oslin, David W.
A1  - Qin, Xuejun
A1  - Agerbo, Esben
A1  - Børglum, Anders D.
A1  - Breen, Gerome
A1  - Erlangsen, Annette
A1  - Esko, Tõnu
A1  - Gelernter, Joel
A1  - Hougaard, David M.
A1  - Kessler, Ronald C.
A1  - Kranzler, Henry R.
A1  - Li, Qingqin S.
A1  - Martin, Nicholas G.
A1  - McIntosh, Andrew M.
A1  - Mors, Ole
A1  - Nordentoft, Merete
A1  - Olsen, Catherine M.
A1  - Porteous, David
A1  - Ursano, Robert J.
A1  - Wasserman, Danuta
A1  - Werge, Thomas
A1  - Whiteman, David C.
A1  - Bulik, Cynthia M.
A1  - Coon, Hilary
A1  - Demontis, Ditte
A1  - Docherty, Anna R.
A1  - Kuo, Po-Hsiu
A1  - Lewis, Cathryn M.
A1  - Mann, J. John
A1  - Renteria, Miguel E.
A1  - Smith, Daniel J.
A1  - Stahl, Eli A.
A1  - Stein, Murray B.
A1  - Streit, Fabian
A1  - Willour, Virginia
A1  - Ruderfer, Douglas M.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. <br><br>METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. <br><br>RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. <br><br>CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/10.1016/j.biopsych.2021.05.029
ID  - ref1
ER  -