TY  - JOUR
PY  - 2021//
TI  - Patterns of balance loss with systematic perturbations in Parkinson's disease and multiple sclerosis
JO  - NeuroRehabilitation
A1  - Allen, Diane D.
A1  - Gadayan, Jessica
A1  - Hughes, Rebecca
A1  - Magdalin, Christine
A1  - Jang, Catherine
A1  - Schultz, Amy
A1  - Scott, Kathryn
A1  - Vivero, Leah
A1  - Lazaro, Rolando L.
A1  - Widener, Gail L.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Multiple sclerosis (MS) and Parkinson's disease (PD) may affect balance differently. However, no studies have compared loss of balance (LOB) patterns following multi-directional perturbations. <br><br>OBJECTIVE: 1) determine reliability of LOB ratings following standardized manual perturbations; 2) compare LOB ratings in MS, PD, and healthy control (HC) groups following perturbations at upper/lower torso, in anterior/posterior, right/left, and rotational directions. <br><br>METHODS: 1) reviewers rated videotaped LOB following perturbations applied by 4 clinicians in 6-10 HCs. 2) three groups (64 MS, 42 PD and 32 HC) received perturbations. LOB ratings following perturbations were analyzed using two-factor mixed ANOVAs for magnitude and prevalence. <br><br>RESULTS: 1) LOB ratings showed moderate to good ICC and good to excellent agreement. 2) MS group showed greater magnitude and prevalence of LOB than PD or HC groups (p <  .001). All groups showed greater LOB from right/left versus anterior/posterior perturbations (p <  .01). PD showed greater LOB from perturbations at upper versus lower torso; MS and HC showed greater LOB from posterior versus anterior perturbations. <br><br>CONCLUSIONS: Our reliable rating scale showed differences in patterns of LOB following manual perturbations in MS, PD, and HC. Clinically accessible and reliable assessment of LOB could facilitate targeted perturbation-based interventions and reduce falls in vulnerable populations.<p />  <p>Language: en</p>
LA  - en
SN  - 1053-8135
UR  - http://dx.doi.org/10.3233/NRE-210200
ID  - ref1
ER  -