TY  - JOUR
PY  - 2021//
TI  - Violent suicide attempt history in elderly patients with bipolar disorder: the role of sex, abdominal obesity, and verbal memory: results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)
JO  - Journal of affective disorders
A1  - Lengvenyte, Aiste
A1  - Aouizerate, Bruno
A1  - Aubin, Valérie
A1  - Loftus, Josephine
A1  - Marlinge, Emeline
A1  - Belzeaux, Raoul
A1  - Dubertret, Caroline
A1  - Gard, Sebastien
A1  - Haffen, Emmanuel
A1  - Schwan, Raymund
A1  - Llorca, Pierre-Michel
A1  - Passerieux, Christine
A1  - Roux, Paul
A1  - Polosan, Mircea
A1  - Etain, Bruno
A1  - Leboyer, Marion
A1  - Courtet, Philippe
A1  - Olié, Emilie
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND:. Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD. <br><br>METHODS:. From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report. <br><br>RESULTS:. Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p <.001, p = .014, and p = .006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00 - 1.05, p = .018; Exp(B) 2.16, CI 1.00 - 4.64, p = .009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA. LIMITATIONS:. Cross-sectional design and retrospective reporting. <br><br>CONCLUSIONS:. Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2021.09.097
ID  - ref1
ER  -