TY  - JOUR
PY  - 2021//
TI  - Continuity of genetic risk for aggressive behavior across the life-course
JO  - Behavior genetics
A1  - Van der Laan, Camiel M.
A1  - Morosoli-García, José J.
A1  - van de Weijer, Steve G. A.
A1  - Colodro-Conde, Lucia
A1  - Lupton, Michelle K.
A1  - Mitchell, Brittany L.
A1  - McAloney, Kerrie
A1  - Parker, Richard
A1  - Burns, Jane M.
A1  - Hickie, Ian B.
A1  - Pool, René
A1  - Hottenga, Jouke-Jan
A1  - Martin, Nicholas G.
A1  - Medland, Sarah E.
A1  - Nivard, Michel G.
A1  - Boomsma, Dorret I.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.<p />  <p>Language: en</p>
LA  - en
SN  - 0001-8244
UR  - http://dx.doi.org/10.1007/s10519-021-10076-6
ID  - ref1
ER  -