TY  - JOUR
PY  - 2021//
TI  - A role for the cortex in sleep-wake regulation
JO  - Nature neuroscience
A1  - Krone, Lukas B.
A1  - Yamagata, Tomoko
A1  - Blanco-Duque, Cristina
A1  - Guillaumin, Mathilde C. C.
A1  - Kahn, Martin C.
A1  - van der Vinne, Vincent
A1  - McKillop, Laura E.
A1  - Tam, Shu K. E.
A1  - Peirson, Stuart N.
A1  - Akerman, Colin J.
A1  - Hoerder-Suabedissen, Anna
A1  - Molnár, Zoltán
A1  - Vyazovskiy, Vladyslav V.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.<p />  <p>Language: en</p>
LA  - en
SN  - 1097-6256
UR  - http://dx.doi.org/10.1038/s41593-021-00894-6
ID  - ref1
ER  -