TY  - JOUR
PY  - 2021//
TI  - Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression
JO  - Neurobiology of aging
A1  - Lin, Chemin
A1  - Huang, Chih-Mao
A1  - Karim, Helmet T.
A1  - Liu, Ho-Ling
A1  - Lee, Tatia Mei-Chun
A1  - Wu, Changwei W.
A1  - Toh, Cheng Hong
A1  - Tsai, Yun-Fang
A1  - Yen, Tzung-Hai
A1  - Lee, Shwu-Hua
SP  - 60
EP  - 67
VL  - 103
IS  - 
N2  - Late-life depression (LLD) is associated with greater risk of suicide and white matter hyperintensities (WMH), which are also found in suicide attempters regardless of age. Greater periventricular WMH are related to worse cognitive function. We investigated the spatial distribution of WMH in suicide attempters with LLD and its association with cognitive function. We recruited 114 participants with LLD (34 with history of suicide attempt and 80 without) and 47 older adult controls (individuals without LLD or history of suicide attempt). WMH were quantified by an automated segmentation algorithm and were classified into different regions. Suicide attempters with LLD had significantly higher global WMH (F3, 150 = 2.856, p = 0.039) and periventricular WMH (F3, 150 = 3.635, p = 0.014) compared to other groups. Suicide attempters with high WMH had significantly lower executive function, which could be an underlying mechanism for cognitive decline in older adults with suicidality.<p />  <p>Language: en</p>
LA  - en
SN  - 0197-4580
UR  - http://dx.doi.org/10.1016/j.neurobiolaging.2020.12.016
ID  - ref1
ER  -