TY  - JOUR
PY  - 2021//
TI  - The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults
JO  - Human brain mapping
A1  - Wesarg, Christiane
A1  - Veer, Ilya M.
A1  - Oei, Nicole Y. L.
A1  - Daedelow, Laura S.
A1  - Lett, Tristram A.
A1  - Banaschewski, Tobias
A1  - Barker, Gareth J.
A1  - Bokde, Arun L. W.
A1  - Quinlan, Erin Burke
A1  - Desrivieres, Sylvane
A1  - Flor, Herta
A1  - Grigis, Antoine
A1  - Garavan, Hugh
A1  - Brühl, Rüdiger
A1  - Martinot, Jean-Luc
A1  - Artiges, Eric
A1  - Nees, Frauke
A1  - Orfanos, Dimitri Papadopoulos
A1  - Poustka, Luise
A1  - Hohmann, Sarah
A1  - Fröhner, Juliane H.
A1  - Smolka, Michael N.
A1  - Whelan, Robert
A1  - Schumann, Gunter
A1  - Heinz, Andreas
A1  - Walter, Henrik
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p < .025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology.<p />  <p>Language: en</p>
LA  - en
SN  - 1065-9471
UR  - http://dx.doi.org/10.1002/hbm.25433
ID  - ref1
ER  -