TY  - JOUR
PY  - 2021//
TI  - Impact of motor subtype on non-motor symptoms and fall-related features in patients with early Parkinson's disease
JO  - Geriatrics and gerontology international
A1  - Kwon, Kyum-Yil
A1  - Lee, Eun Ji
A1  - Lee, Mina
A1  - Ju, Hyunjin
A1  - Im, Kayeong
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - AIM: Clinical implications for motor phenotypes of Parkinson's disease (PD) remain to be further elucidated, particularly at the early stages of the disease. We aimed to compare the non-motor and fall-related features between tremor-dominant (TD) and postural instability-gait difficulty (PIGD) subtypes in patients with early PD. <br><br>METHODS: PD was categorized into TD, intermediate and PIGD types, according to the literature. Not only motor symptoms, but also non-motor symptoms for global cognition, depression, anxiety, fatigue and dysautonomia, were measured in detail. In addition, fall-related features, including a previous history of falls, fear of fall measurement and gait freezing were assessed. <br><br>RESULTS: In patients with early PD (disease duration no more than 5 years), 35 patients with TD-type PD and 31 patients with PIGD-type PD were finally evaluated for the study. Compared with the TD group, the PIGD group showed higher fatigue, gastrointestinal dysfunction and fall-related parameter scores. Moreover, the PIGD scores were significantly correlated with all of those symptoms. <br><br>CONCLUSIONS: Our findings suggest that PIGD is significantly linked to fatigue, gastrointestinal dysfunction and fall-related features during the early stages of PD. Geriatr Gerontol Int ••; ••: ••-•• Geriatr Gerontol Int 2021; ••: ••-••.<p />  <p>Language: en</p>
LA  - en
SN  - 1444-1586
UR  - http://dx.doi.org/10.1111/ggi.14156
ID  - ref1
ER  -