TY  - JOUR
PY  - 2021//
TI  - Risk levels of herb-induced liver injury in Korea: from a meta-analysis
JO  - Integrative medicine research
A1  - Lee, Nam-Hun
A1  - Lee, Ga-Young
A1  - Park, Chan-Ran
A1  - Kim, Sul-Ki
A1  - Ahn, Yo-Chan
A1  - Cho, Jung-Hyo
A1  - Son, Chang-Gue
SP  - e100705
EP  - e100705
VL  - 10
IS  - 3
N2  - BACKGROUND: As the use of herbal medicines increased worldwide, there has been concern about the risk of herb-induced liver injury (HILI). Many clinical studies have assessed the risk of HILI in Korea. <br><br>METHODS: Therefore, we conducted a meta-analysis of the incidence of HILI in Korea, by analyzing nine clinical studies. These involved 8625 participants (3274 males; 5351 females), including 436 outpatients (three studies) and 8189 inpatients (six studies). <br><br>RESULTS: As a result, the overall incidence of HILI in Korea was 0.49% (95% CI 0.33-0.74%), and it was 0.57% in males and 0.30% in females. We found a similar incidence of HILI in prospective (0.51%) and retrospective (0.50%) studies. The incidence of HILI was higher in inpatients (0.62%) than outpatients (0.03%). <br><br>CONCLUSION: Although there are limitations regarding study quality and the number of participants, we systematically estimated the risk of HILI in Korea. We anticipate this study would be a helpful information for prescribing herbal medicines and researching the safety of herbs.<p />  <p>Language: en</p>
LA  - en
SN  - 2213-4220
UR  - http://dx.doi.org/10.1016/j.imr.2020.100705
ID  - ref1
ER  -