TY  - JOUR
PY  - 2021//
TI  - A rare case of suicide by ingestion of phorate: a case report and a review of the literature
JO  - Healthcare (Basel, Switzerland)
A1  - Montana, Angelo
A1  - Rapisarda, Venerando
A1  - Esposito, Massimiliano
A1  - Amico, Francesco
A1  - Cocimano, Giuseppe
A1  - Nunno, Nunzio Di
A1  - Ledda, Caterina
A1  - Salerno, Monica
SP  - e131
EP  - e131
VL  - 9
IS  - 2
N2  - Phorate is a systemic organophosphorus pesticide (OP) that acts by inhibiting cholinesterases. Recent studies have reported that long-term low/moderate exposure to OP could be correlated with impaired cardiovascular and pulmonary function and other neurological effects. A 70-year-old farmer died after an intention ingestion of a granular powder mixed with water. He was employed on a farm for over 50 years producing fruit and vegetables, and for about 20 years, he had also applied pesticides. In the last 15 years, he used phorate predominantly. The Phorate concentration detected in gastric contents was 3.29 µg/mL. Chronic exposure to phorate is experimentally studied by histopathological changes observed in the kidney. In the light of current literature, our case confirms that there is an association between renal damage and chronic exposure to phorate in a subject exposed for years to the pesticide. Autopsies and toxicological analyses play a key role in the reconstruction of the dynamics, including the cause of the death.<p />  <p>Language: en</p>
LA  - en
SN  - 2227-9032
UR  - http://dx.doi.org/10.3390/healthcare9020131
ID  - ref1
ER  -