TY  - JOUR
PY  - 2021//
TI  - Biomarkers of memory variability in traumatic brain injury
JO  - Brain communications
A1  - Adamovich-Zeitlin, Richard
A1  - Wanda, Paul A.
A1  - Solomon, Ethan
A1  - Phan, Tung
A1  - Lega, Bradley
A1  - Jobst, Barbara C.
A1  - Gross, Robert E.
A1  - Ding, Kan
A1  - Diaz-Arrastia, Ramon
A1  - Kahana, Michael J.
SP  - fcaa202
EP  - fcaa202
VL  - 3
IS  - 1
N2  - Traumatic brain injury is a leading cause of cognitive disability and is often associated with significant impairment in episodic memory. In traumatic brain injury survivors, as in healthy controls, there is marked variability between individuals in memory ability. Using recordings from indwelling electrodes, we characterized and compared the oscillatory biomarkers of mnemonic variability in two cohorts of epilepsy patients: a group with a history of moderate-to-severe traumatic brain injury (n = 37) and a group of controls without traumatic brain injury (n = 111) closely matched for demographics and electrode coverage. Analysis of these recordings demonstrated that increased high-frequency power and decreased theta power across a broad set of brain regions mark periods of successful memory formation in both groups. As features in a logistic-regression classifier, spectral power biomarkers effectively predicted recall probability, with little difference between traumatic brain injury patients and controls. The two groups also displayed similar patterns of theta-frequency connectivity during successful encoding periods. These biomarkers of successful memory, highly conserved between traumatic brain injury patients and controls, could serve as the basis for novel therapies that target disordered memory across diverse forms of neurological disease.<p />  <p>Language: en</p>
LA  - en
SN  - 2632-1297
UR  - http://dx.doi.org/10.1093/braincomms/fcaa202
ID  - ref1
ER  -