TY  - JOUR
PY  - 2020//
TI  - Socioeconomic Deprivation Index is associated with psychiatric disorders: an observational and genome-wide gene-by-environment interaction analysis in the UK Biobank cohort
JO  - Biological psychiatry
A1  - Ye, Jing
A1  - Wen, Yan
A1  - Sun, Xifang
A1  - Chu, Xiaomeng
A1  - Li, Ping
A1  - Cheng, Bolun
A1  - Cheng, Shiqiang
A1  - Liu, Li
A1  - Zhang, Lu
A1  - Ma, Mei
A1  - Qi, Xin
A1  - Liang, Chujun
A1  - Kafle, Om Prakash
A1  - Jia, Yumeng
A1  - Wu, Cuiyan
A1  - Wang, Sen
A1  - Wang, Xi
A1  - Ning, Yujie
A1  - Sun, Shiquan
A1  - Zhang, Feng
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Psychiatric disorders are among the largest and fastest-growing categories of the global disease burden. However, limited effort has been made to further elucidate associations between socioeconomic factors and psychiatric disorders from a genetic perspective. <br><br>METHODS: We randomly divided 501,882 participants in the UK Biobank cohort with socioeconomic Townsend deprivation index (TDI) data into a discovery cohort and a replication cohort. For both cohorts, we first conducted regression analyses to evaluate the associations between the TDI and common psychiatric disorders or traits, including anxiety, bipolar disorder, self-harm, and depression (based on self-reported depression and Patient Health Questionnaire scores). We then performed a genome-wide gene-by-environment interaction study using PLINK 2.0 with the TDI as an environmental factor to explore interaction effects. <br><br>RESULTS: In the discovery cohort, significant associations were observed between the TDI and psychiatric disorders (p < 4.00 × 10(-16)), including anxiety (odds ratio [OR] = 1.08, 95% confidence interval [CI] = 1.07-1.10), bipolar disorder (OR = 1.42, 95% CI = 1.36-1.48), self-harm (OR = 1.21, 95% CI = 1.19-1.23), self-reported depression (OR = 1.22, 95% CI = 1.20-1.24), and Patient Health Questionnaire scores (β =.07, SE = 0.004). We observed similar significant associations in the replication cohort. In addition, multiple candidate loci were identified by the genome-wide gene-by-environment interaction study, including rs10886438 at 10q26.11 (GRK5) (p = 5.72 × 10(-11)) for Patient Health Questionnaire scores and rs162553 at 2p22.2 (CYP1B1) (p = 2.25 × 10(-9)) for self-harm. <br><br>CONCLUSIONS: Our findings suggest the relevance of the TDI to psychiatric disorders. The genome-wide gene-by-environment interaction study identified several candidate genes interacting with the TDI, providing novel clues for understanding the biological mechanism of associations between the TDI and psychiatric disorders.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/10.1016/j.biopsych.2020.11.019
ID  - ref1
ER  -