TY  - JOUR
PY  - 2021//
TI  - The role of estradiol in traumatic brain injury: mechanism and treatment potential
JO  - International journal of molecular sciences
A1  - Kövesdi, Erzsebet
A1  - Szabó-Meleg, Edina
A1  - Abrahám, István M.
SP  - e11
EP  - e11
VL  - 22
IS  - 1
N2  - Patients surviving traumatic brain injury (TBI) face numerous neurological and neuropsychological problems significantly affecting their quality of life. Extensive  studies over the past decades have investigated pharmacological treatment options in  different animal models, targeting various pathological consequences of TBI. Sex and  gender are known to influence the outcome of TBI in animal models and in patients,  respectively. Apart from its well-known effects on reproduction, 17β-estradiol (E2)  has a neuroprotective role in brain injury. Hence, in this review, we focus on the  effect of E2 in TBI in humans and animals. First, we discuss the clinical  classification and pathomechanism of TBI, the research in animal models, and the  neuroprotective role of E2. Based on the results of animal studies and clinical  trials, we discuss possible E2 targets from early to late events in the  pathomechanism of TBI, including neuroinflammation and possible disturbances of the  endocrine system. Finally, the potential relevance of selective estrogenic compounds  in the treatment of TBI will be discussed.<p />  <p>Language: en</p>
LA  - en
SN  - 1661-6596
UR  - http://dx.doi.org/10.3390/ijms22010011
ID  - ref1
ER  -