TY  - JOUR
PY  - 2020//
TI  - Fixation stability as a biomarker for differentiating mild traumatic brain injury from age matched controls in pediatrics
JO  - Brain injury
A1  - Hunfalvay, Melissa
A1  - Murray, Nicholas P.
A1  - Carrick, Frederick Robert
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVES: Traumatic brain injury (TBI) is an increasingly significant health  concern worldwide, compounded by the difficultly in detection and diagnosis. Fortunately, a growing body of research has identified oculomotor behavior,  specifically fixations, saccades and smooth pursuit eye movements as a promising  endophenotype for neurotrauma. To date, limited research exists using fixation  stability in a comparative study to indicate the presence of a mild TBI (mTBI),  especially in the pediatric population. <br><br>METHODS: The present study examined data  from 91 individuals clinically diagnosed with mTBI and a further 140 age- and  gender-matched controls. They all completed the RightEye fixation stability test  using a remote eye tracker. Participants were compared on five fixation metrics:  Bivariate Contour Ellipse Area (BCEA), Convergence Point, Depth, Disassociated  Phoria, and Targeting Displacement. <br><br>RESULTS: Results were analyzed using one-way  univariate ANOVAs, ROC analysis, and stepwise logistic regression. BCEA results  revealed significant differences between groups with the mTBI group showing a larger  gaze spread, indicative of less ability to keep the eyes close to the target without  deviating. <br><br>CONCLUSIONS: Fixation stability is detrimentally impacted by mTBI in  pediatric patients, and the oculomotor test can be used to differentiate between  those with and without an mTBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-9052
UR  - http://dx.doi.org/10.1080/02699052.2020.1865566
ID  - ref1
ER  -