TY  - JOUR
PY  - 2020//
TI  - Bee sting envenomation severe cases in Manaus, Brazilian Amazon: clinical characteristics and immune markers of case reports
JO  - Revista da Sociedade Brasileira de Medicina Tropical
A1  - Mendonça-da-Silva, Iran
A1  - Monteiro, Wuelton Marcelo
A1  - Sachett, Jacqueline Almeida Gonçalves
A1  - Barbosa, Endila Souza
A1  - Cordeiro-Dos-Santos, Marcelo
A1  - Lacerda, Marcus Vinícius Guimarães
A1  - Melo, Gisely Cardoso
A1  - Costa, Allyson Guimarães
A1  - Val, Fernando Fonseca Almeida
SP  - e20200319
EP  - e20200319
VL  - 54
IS  - 
N2  - Bee venom is a natural toxin composed of several peptides. Massive envenoming causes severe local and systemic reactions. We report two cases of severe bee envenomation, of which one was fatal. We also describe clinical characteristics and immune markers. Both victims suffered from respiratory distress, renal failure, rhabdomyolysis, and shock. They required invasive mechanical ventilation, vasoactive drugs, and renal replacement therapy. Moreover, serum levels of chemokines, cytokines, and cell-free circulating nucleic acids demonstrated an intense inflammatory process. Massive envenoming produced systemic injury in the victims, with an uncontrolled inflammatory response, and a more significant chemotactic response in the fatal case.<p />  <p>Language: en</p>
LA  - en
SN  - 0037-8682
UR  - http://dx.doi.org/10.1590/0037-8682-0319-2021
ID  - ref1
ER  -