TY  - JOUR
PY  - 2020//
TI  - Clinical features and mortality-related factors of extensive burns among young adults: the Kunshan disaster experience
JO  - Annals of translational medicine
A1  - Huang, Ying-Zi
A1  - Lu, Guo-Zhong
A1  - Zhao, Hong-Sheng
A1  - Liu, Li-Jun
A1  - Jin, Jun
A1  - Wu, Yun-Fu
A1  - Wu, Jian
A1  - Zhao, Fu-Li
A1  - Liu, Ning
A1  - Liu, Wen-Ming
A1  - Liu, Long
A1  - Zhu, Tuan-Jie
A1  - Chen, Er-Zhen
A1  - Gu, Qin
A1  - Ye, Hong-Wei
A1  - Xi, Xiu-Ming
A1  - Du, Bin
A1  - Yi, Yang
A1  - Qiu, Hai-Bo
SP  - e1053
EP  - e1053
VL  - 8
IS  - 17
N2  - BACKGROUND: The aim of the study was to identify the clinical features and the factors associated with burn induced mortality among young adults after exposure to indoor explosion and fire.     Methods: This is an observational study which included burn patients who were admitted to eighteen ICUs after a fire disaster. Epidemiologic and clinical characteristics, as well as therapy were recorded. The primary outcome was 90-day mortality. The mortality-related factors were also analyzed.     Results: There were 167 burn patients enrolled in the study, the median age was 38 years, 62 (37.1%) patients died within 90 days. Seventy-one percent of patients had a burn size ≥90% TBSA, and 73.7% of patients had a full-thickness burn area above 50% TBSA. The survivors had lower Baux scores, and received earlier escharectomy and autologous skin grafts. The 50% mortality rates (LA50s) for burn size and full-thickness burn area were 95.8% and 88.6% TBSA, respectively. The multivariate analysis showed that full-thickness burn area over 50% TBSA and residual burned surface area (RBSA)/TBSA at 28 days were strong predictors of mortality among burn patients (odds ratio 2.55; 95% CI, 1.01 to 6.44, P=0.047; odds ratio 1.07; 95% CI, 1.04 to 1.09, P<0.001). The ROC curve-based cut-off values of RBSA/TBSA at 28 days for predicting 90-day mortality were 62.5%.     Conclusions: Burn size and full-thickness burn area were the main risk factors for poor outcome in patients with extensive burns. Earlier escharectomy and autologous skin grafts may improve outcomes.<p />  <p>Language: en</p>
LA  - en
SN  - 2305-5839
UR  - http://dx.doi.org/10.21037/atm-20-288
ID  - ref1
ER  -