TY  - JOUR
PY  - 2020//
TI  - Evaluation of human brain hyperthermia using exergy balance equation
JO  - Journal of thermal biology
A1  - Mahmood, Imran
A1  - Raza, Ali
A1  - Mehmood, Aamir
A1  - Ahmad, Nasir
A1  - Arif, Khalid
SP  - e102723
EP  - e102723
VL  - 93
IS  - 
N2  - Hyperthermia is caused by disturbance in the thermoregulatory system of the human body and requires emergency treatment to prevent disability or possible mortality. To design any therapeutic device for hyperthermia, an exhaustive effort is required to establish the extremities of such thermal traumas. In this context, the authors have incorporated the human-body exergy-balance equation to compute the hyperthermia thresholds. This is a pioneer attempt to model hyperthermia states. An induced-hyperthermia technique is used to evaluate the extremities of metabolic heat generation and other dependent parameters. Moreover, a case study is also presented to calculate the parameters of prime importance i.e. exergy consumption (EC) and entropy generation rate (δSg) to provide the body's accumulative and exhaustive thermal energy maxima, respectively. Furthermore, the thresholds have been evaluated and simulated by the varying body and/or environmental conditions. The resulting states have been analysed to setup critical ranges to provide the guidelines for rehabilitation therapy. A thermal manikin has also been developed, mimicking the blood circulation in humans, to further substantiate the use of an exergy-based approach. The results indicate that the exergy-based approach is well suited to model hyperthermia at pathophysiological boundaries, contrary to existing approaches which predominantly are limited to the physiological domain.<p />  <p>Language: en</p>
LA  - en
SN  - 0306-4565
UR  - http://dx.doi.org/10.1016/j.jtherbio.2020.102723
ID  - ref1
ER  -