TY  - JOUR
PY  - 2020//
TI  - Factors associated with single versus multiple suicide attempts in depressive disorders
JO  - Journal of affective disorders
A1  - Tondo, Leonardo
A1  - Baldessarini, Ross J.
A1  - Barbuti, Margherita
A1  - Colombini, Paola
A1  - Angst, Jules
A1  - Azorin, Jean-Michel
A1  - Bowden, Charles L.
A1  - Mosolov, Sergey
A1  - Young, Allan H.
A1  - Vieta, Eduard
A1  - Perugi, Giulio
SP  - 306
EP  - 312
VL  - 277
IS  - 
N2  - BACKGROUND: Many risk factors for suicidal behavior have been identified. Much less has been done to associate risk factors with recurrence of suicidal behavior.     METHODS: We compared prevalence of 30 potential risk factors among 8496 depressive patient-subjects from the BRIDGE consortium with no (NSA, n = 6267), one (1SA, n = 1123), or repeated (≥2) suicide attempts (RSA, n = 1106).     RESULTS: Prevalence of most factors ranked: RSA ≥ 1SA > NSA, with a notable opposite trend for the diagnosis of type II bipolar disorder (BD). Factors independently and significantly more present among RSA than 1SA subjects were: borderline personality, substance abuse, mood-switching with antidepressant treatment, female sex, and unsatisfactory response to antidepressant treatment. There also were notably strong associations of RSA with type I or probable BD and associated factors, including family history of BD, young onset, mixed and psychotic features.     LIMITATIONS: Potential effects of treatment on risk of suicidal acts could not be evaluated adequately, as well as associations between levels of suicidal behavior and eventual death by suicide.     CONCLUSIONS: In a large cohort of depressive patients, there were significant associations not only with suicidal behavior generally, but also with the intensity of suicide attempts.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2020.08.021
ID  - ref1
ER  -