TY  - JOUR
PY  - 2020//
TI  - Catalonia Suicide Risk Code Epidemiology (CSRC-Epi) study: protocol for a population-representative nested case-control study of suicide attempts in Catalonia, Spain
JO  - BMJ open
A1  - Mortier, Philippe
A1  - Vilagut, Gemma
A1  - Puértolas Gracia, Beatriz
A1  - De Inés Trujillo, Ana
A1  - Alayo Bueno, Itxaso
A1  - Ballester Coma, Laura
A1  - Blasco Cubedo, María Jesús
A1  - Cardoner, Narcís
A1  - Colls, Cristina
A1  - Elices, Matilde
A1  - Garcia-Altes, Anna
A1  - Gené Badia, Manel
A1  - Gómez Sánchez, Javier
A1  - Martín Sánchez, Mario
A1  - Morros, Rosa
A1  - Prat Pubill, Bibiana
A1  - Qin, Ping
A1  - Mehlum, Lars
A1  - Kessler, Ronald C.
A1  - Palao, Diego
A1  - Perez Sola, Victor
A1  - Alonso, Jordi
A1  - CODIRISC Epidemiology Study Group, 
SP  - ee037365
EP  - ee037365
VL  - 10
IS  - 7
N2  - INTRODUCTION: Suicide attempts represent an important public health burden. Centralised electronic health record (EHR) systems have high potential to provide suicide attempt surveillance, to inform public health action aimed at reducing risk for suicide attempt in the population, and to provide data-driven clinical decision support for suicide risk assessment across healthcare settings. To exploit this potential, we designed the Catalonia Suicide Risk Code Epidemiology (CSRC-Epi) study. Using centralised EHR data from the entire public healthcare system of Catalonia, Spain, the CSRC-Epi study aims to estimate reliable suicide attempt incidence rates, identify suicide attempt risk factors and develop validated suicide attempt risk prediction tools.     METHODS AND ANALYSIS: The CSRC-Epi study is registry-based study, specifically, a two-stage exposure-enriched nested case-control study of suicide attempts during the period 2014-2019 in Catalonia, Spain. The primary study outcome consists of first and repeat attempts during the observation period. Cases will come from a case register linked to a suicide attempt surveillance programme, which offers in-depth psychiatric evaluations to all Catalan residents who present to clinical care with any suspected risk for suicide. Predictor variables will come from centralised EHR systems representing all relevant healthcare settings. The study's sampling frame will be constructed using population-representative administrative lists of Catalan residents. Inverse probability weights will restore representativeness of the original population. Analysis will include the calculation of age-standardised and sex-standardised suicide attempt incidence rates. Logistic regression will identify suicide attempt risk factors on the individual level (ie, relative risk) and the population level (ie, population attributable risk proportions). Machine learning techniques will be used to develop suicide attempt risk prediction tools.     ETHICS AND DISSEMINATION: This protocol is approved by the Parc de Salut Mar Clinical Research Ethics Committee (2017/7431/I). Dissemination will include peer-reviewed scientific publications, scientific reports for hospital and government authorities, and updated clinical guidelines.     TRIAL REGISTRATION NUMBER: NCT04235127.<p />  <p>Language: en</p>
LA  - en
SN  - 2044-6055
UR  - http://dx.doi.org/10.1136/bmjopen-2020-037365
ID  - ref1
ER  -