TY  - JOUR
PY  - 2020//
TI  - Putative cut-points in sarcopenia components and incident adverse health outcomes: an SDOC analysis
JO  - Journal of the American Geriatrics Society
A1  - Cawthon, Peggy M.
A1  - Manini, Todd
A1  - Patel, Sheena M.
A1  - Newman, Anne
A1  - Travison, Thomas
A1  - Kiel, Douglas P.
A1  - Santanasto, Adam J.
A1  - Ensrud, Kristine E.
A1  - Xue, Qian-Li
A1  - Shardell, Michelle
A1  - Duchowny, Kate
A1  - Erlandson, Kristine M.
A1  - Pencina, Karol M.
A1  - Fielding, Roger A.
A1  - Magaziner, Jay
A1  - Kwok, Timothy
A1  - Karlsson, Magnus
A1  - Ohlsson, Claes
A1  - Mellström, Dan
A1  - Hirani, Vasant
A1  - Ribom, Eva
A1  - Correa-De-Araujo, Rosaly
A1  - Bhasin, Shalender
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVES: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht2 ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality).     DESIGN: Individual-level, sex-stratified pooled analysis. We calculated odds ratios (ORs) or hazard ratios (HRs) for incident falls, mobility limitation, hip fractures, and mortality. Follow-up time ranged from 1 year for falls to 8.8 ± 2.3 years for mortality.     SETTING: Eight prospective observational cohort studies.     PARTICIPANTS: A total of 13,421 community-dwelling men and 4,828 community-dwelling women.     MEASUREMENTS Grip strength by hand dynamometry, gait speed, and lean mass by DXA.     RESULTS: Low grip strength (absolute or standardized to body size/composition) was associated with incident outcomes, usually independently of slowness, in both men and women. ORs and HRs generally ranged from 1.2 to 3.0 for those below vs above the cut-point. DXA lean mass was not consistently associated with these outcomes. When considered together, those who had both muscle weakness by absolute grip strength (<35.5 kg in men and <20 kg in women) and slowness were consistently more likely to have a fall, hip fracture, mobility limitation, or die than those without either slowness or muscle weakness.     CONCLUSION: Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia.<p />  <p>Language: en</p>
LA  - en
SN  - 0002-8614
UR  - http://dx.doi.org/10.1111/jgs.16517
ID  - ref1
ER  -