TY  - JOUR
PY  - 2020//
TI  - Evolving white matter injury following pediatric traumatic brain injury
JO  - Journal of neurotrauma
A1  - Bartnik-Olson, Brenda Lynn
A1  - Holshouser, Barbara A.
A1  - Ghosh, Nirmalya
A1  - Oyoyo, Udo
A1  - Nichols, Joy
A1  - Pivonka-Jones, Jamie
A1  - Tong, Karen
A1  - Ashwal, Stephen
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - This study is unique in that it examines the evolution of white matter injury very early and at 12 months post-injury in pediatric patients following traumatic brain injury (TBI). Diffusion tensor imaging (DTI) was acquired at 2 time points, acutely at 6 - 17 days and 12 months following a complicated mild (cMild)/moderate (mod) or TBI. Regional measures of anisotropy and diffusivity were compared between TBI groups and against a group of age-matched healthy controls and used to predict performance on measures of attention, memory, and intellectual functioning at 12-months post-injury. Analysis of the acute DTI data using tract based spatial statistics (TBSS) revealed a small number of regional decreases in fractional anisotropy (FA) in both the cMild/mod and severe TBI groups when compared to controls. These changes were observed in the occipital white matter, anterior limb of the internal capsule (ALIC)/basal ganglia and corpus callosum. The severe TBI group showed regional differences in axial diffusivity (AD) in the brainstem and corpus callosum that were not seen in the cMild/mod TBI group. By 12-months, widespread decreases in FA and increases in apparent diffusion coefficient (ADC), AD, and radial diffusivity (RD) were observed in both TBI groups compared to controls, with the overall number of regions with abnormal DTI metrics increasing over time. The early changes in regional DTI metrics were associated with 12 month performance IQ (PIQ) scores. These findings suggest that there may be regional differences in the brain's reparative processes or that mechanisms associated with the brain's plasticity to recover may also be region based.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2019.6574
ID  - ref1
ER  -