TY  - JOUR
PY  - 2020//
TI  - Depression with and without a history of psychotic symptoms in the general population: sociodemographic and clinical characteristics
JO  - Journal of affective disorders
A1  - Benard, Victoire
A1  - Pignon, Baptiste
A1  - Geoffroy, Pierre-Alexis
A1  - Benradia, Imane
A1  - Roelandt, Jean-Luc
A1  - Rolland, Benjamin
A1  - Fovet, Thomas
A1  - D'Hondt, Fabien
A1  - Thomas, Pierre
A1  - Vaiva, Guillaume
A1  - Amad, Ali
SP  - 247
EP  - 251
VL  - 273
IS  - 
N2  - BACKGROUND: The aim of this study was to find the sociodemographic and clinical characteristics of major depressive episode (MDE) with (MDE-HPS+) and without a history of psychotic symptoms (MDE-HPS) in the general population.   METHODS: The Mental Health in the General Population survey interviewed 38,694 individuals in France by using the MINI. The prevalence and sociodemographic and clinical correlates of MDE-HPS+ were assessed.   RESULTS: Of the sample, 11.2% were diagnosed with current MDE and among them, 39.3% presented a history of at least one psychotic symptom (hallucination or delusion). Patients with MDE-HPS+ were younger with more severe social impairment than those with MDE-HPS-. We also found a higher proportion of three generations of migrants in the MDE-HPS+ group. Comorbid psychiatric disorders such as a history of a manic episode, alcohol use disorder, social anxiety, generalized anxiety disorder, and a personal history of a suicide attempt were more frequent in patients with MDE-HPS+ than in those with MDE-HPS-. Finally, we found a specific gradient of severity for psychiatric comorbid disorders depending on the number of psychotic symptoms lifetime in MDE.   LIMITATIONS: The study also has an observational cross-sectional design that does not permit causal inferences, and it is difficult to eliminate recall bias and reporting errors.   CONCLUSION: In the general population, patients with MDE-HPS+, when compared to MDE-HPS-, presented with a more severe clinical profile, with increased rates of psychiatric comorbidities, particularly a history of bipolar disorder and a history of a suicide attempt.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2020.04.048
ID  - ref1
ER  -