TY  - JOUR
PY  - 2020//
TI  - Biomarkers of suicidal behaviors: a comprehensive critical review
JO  - Advances in clinical chemistry
A1  - Capuzzi, Enrico
A1  - Caldiroli, Alice
A1  - Capellazzi, Martina
A1  - Tagliabue, Ilaria
A1  - Buoli, Massimiliano
A1  - Clerici, Massimo
SP  - 179
EP  - 216
VL  - 96
IS  - 
N2  - Suicide is a relevant worldwide public health problem. Many studies have shown that different demographic and clinical factors are potentially associated with suicidal behavior. Other studies have reported data about the role of biomarkers in the onset of suicidal behaviors. Specifically, researchers have found that suicidal risk may be increased by abnormalities in serotonergic system, hypothalamic-pituitary-adrenal axis, lipid metabolism, immune system and neuronal plasticity. The identification of specific biological parameters associated with self-harm may be helpful to implement prevention strategies and also to detect new therapeutic strategies. In this review, we summarize and analyze the results of main studies about neurobiological mechanisms related to suicidal behavior, also exploring the possible interconnection between the different biological systems.<br><br>© 2020 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0065-2423
UR  - http://dx.doi.org/10.1016/bs.acc.2019.11.005
ID  - ref1
ER  -